Varaico: Literature-Extracted Genetic Variants

Gene:PON2
Variant:p.S311C
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PON2

NM_000305.3:p.S311C

Associated Papers

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

Association of Paraoxonase-1 (p.L55M) and Paraoxonase-2 (p.S311C) polymorphisms with coronary artery disease in North Indian Punjabi population.

Bhat MA et al.

Frontiers in Endocrinology, 2025

A Case-Control Study Supports Genetic Contribution of the PON Gene Family in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease.

Van Dijck E et al.

Antioxidants (basel, Switzerland), 2024

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice.

Sreekumar PG et al.

Antioxidants (basel, Switzerland), 2023

Role of paraoxonase 1 activity and PON1 gene polymorphisms in sickle cell disease.

Menezes JF et al.

Scientific Reports, 2023

Proteomic Exploration of Paraoxonase 1 Function in Health and Disease.

Jakubowski H

International Journal of Molecular Sciences, 2023

Germline genetic variants are associated with development of insulin-dependent diabetes in cancer patients treated with immune checkpoint inhibitors.

Caulfield JI et al.

Journal for Immunotherapy of Cancer, 2023

Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.

Boukhalfa W et al.

Frontiers in Aging Neuroscience, 2023

37342358 (PubMed )
Supplement: Table_2.XLSX › Table_2_SNPnexus_annotation

Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.

Hagmann H et al.

Cells, 2022

Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population.

Shi M et al.

Journal of the American Heart Association, 2022

36193932 (PubMed )
Supplement: JAH3-11-e025245-s001.pdf

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

Young WJ et al.

Nature Communications, 2022

36050321 (PubMed )
Supplement: 41467_2022_32821_MOESM4_ESM.xlsx › Data_12a

Coronary Heart Disease in Type 2 Diabetes Mellitus: Genetic Factors and Their Mechanisms, Gene-Gene, and Gene-Environment Interactions in the Asian Populations.

Zarkasi KA et al.

International Journal of Environmental Research and Public Health, 2022

Case report: Two unique nonsense mutations in HTRA1-related cerebral small vessel disease in a Chinese population and literature review.

Chen W et al.

Frontiers in Neurology, 2022

36619910 (PubMed )
Supplement: Data_Sheet_3.ZIP › case-C › 3.________ › CA2245B________.__________________________________.xlsx › sheet1

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations.

Pei J et al.

Clinical Epigenetics, 2021

33757590 (PubMed )
Supplement: 13148_2021_1043_MOESM14_ESM.xlsx › Supplementary_Table_6B

The Relevance of Noncoding DNA Variations of Paraoxonase Gene Cluster in Atherosclerosis-Related Diseases.

Wysocka A et al.

International Journal of Molecular Sciences, 2021

Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease.

Parween F et al.

Plos One, 2021

Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis.

Kunjantarachot A et al.

Reproductive Biology and Endocrinology : Rb&e, 2020

WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2.

Carusone TM et al.

Cell Death & Disease, 2020

Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: Genotypic and phenotypic evaluation.

Shokri Y et al.

Diabetes Research and Clinical Practice, 2020

Susceptibility of PON1/PON2 Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population.

Pan Y et al.

Pharmacogenomics and Personalized Medicine, 2020

Association of SOD2 A16V and PON2 S311C polymorphisms with polycystic ovary syndrome in Chinese women.

Liu Q et al.

Journal of Endocrinological Investigation, 2019

Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients.

Bhuvaneshwar K et al.

Bmc Cancer, 2019

30991985 (PubMed )
Supplement: 12885_2019_5474_MOESM4_ESM.xlsx › 2016NovDec12_2016Dec12_85_15_GL

Paraoxonase 1 Gene L55M Polymorphism and Paraoxonase 1 Activity in Obstructive Sleep Apnea Patients.

Płóciniczak A et al.

Advances in Experimental Medicine and Biology, 2019

Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes.

Mahrooz A et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2018

Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants.

Dardiotis E et al.

Environment International, 2018

PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease.

González-Castro TB et al.

Biomarkers in Medicine, 2018

Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance.

Shunmoogam N et al.

Vascular Health and Risk Management, 2018

Association of PON2 Gene Polymorphisms (Ser311Cys and Ala148Gly) With the Risk of Developing Type 2 Diabetes Mellitus in the Chinese Population.

Ren H et al.

Frontiers in Endocrinology, 2018

Paraoxonase-2 variants potentially influence insulin resistance, beta-cell function, and their interrelationships with alanine aminotransferase in type 2 diabetes.

Qujeq D et al.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences, 2018

A Meta-Analysis on the Relationship of the PON Genes and Alzheimer Disease.

Nie Y et al.

Journal of Geriatric Psychiatry and Neurology, 2017

Regulation of the epithelial Na+ channel by paraoxonase-2.

Shi S et al.

The Journal of Biological Chemistry, 2017

A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK.

Morgan S et al.

Brain : a Journal of Neurology, 2017

28430856 (PubMed )
Supplement: awx082_Supp.pdf

Paraoxonase 1 and 2 gene variants and the ischemic stroke risk in Gran Canaria population: an association study and meta-analysis.

Rodríguez-Esparragón F et al.

The International Journal of Neuroscience, 2017

Association Between Paraoxonase 2 Ser311Cys Polymorphism and Coronary Heart Disease Risk: A Meta-Analysis.

Chen ML et al.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 2016

Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians.

Sorokin AV et al.

Cardiology in the Young, 2016

Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.

Park HJ et al.

Journal of Molecular Neuroscience : Mn, 2015

Identification of HPV integration and gene mutation in HeLa cell line by integrated analysis of RNA-Seq and MS/MS data.

Sun H et al.

Journal of Proteome Research, 2015

25698088 (PubMed )
Supplement: pr500944c_si_009.xlsx › SNV

Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.

Khodaeian M et al.

Journal of Diabetes Research, 2015

Targeted exon capture and sequencing in sporadic amyotrophic lateral sclerosis.

Couthouis J et al.

Plos Genetics, 2014

Renin-angiotensin system genetic polymorphisms and brain white matter lesions in older Australians.

Assareh AA et al.

American Journal of Hypertension, 2014

Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis.

Litovkina O et al.

Gene, 2014

Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort.

Li S et al.

Journal of Assisted Reproduction and Genetics, 2014

Genetic score based on high-risk genetic polymorphisms and early onset of ischemic heart disease in an Italian cohort of ischemic patients.

Vecoli C et al.

Thrombosis Research, 2014

Antioxidant defense enzyme genes and asthma susceptibility: gender-specific effects and heterogeneity in gene-gene interactions between pathogenetic variants of the disease.

Polonikov AV et al.

Biomed Research International, 2014

Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy.

Wang J et al.

Molecular Medicine Reports, 2013

Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing.

Kenna KP et al.

Journal of Medical Genetics, 2013

23881933 (PubMed )
Supplement: jmedgenet-2013-101795-s1.pdf

Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients.

Han L et al.

Genetics and Molecular Research : Gmr, 2013

Association of polymorphism of ser311cys paraoxonase-2 gene with type 2 diabetes mellitus in iran.

Andalib S et al.

International Journal of Preventive Medicine, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."