Varaico: Literature-Extracted Genetic Variants

Gene:PON2
Variant:p.A148G
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PON2

NM_000305.3:p.A148G

Associated Papers

Proteogenomic Profiling of Treatment-Naïve Metastatic Malignant Melanoma.

Kuras M et al.

Cancers, 2025

40075679 (PubMed )
Supplement: cancers-17-00832-s001.zip › Table_S5._SAAVs.xlsx › Table_S5A

A Case-Control Study Supports Genetic Contribution of the PON Gene Family in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease.

Van Dijck E et al.

Antioxidants (basel, Switzerland), 2024

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice.

Sreekumar PG et al.

Antioxidants (basel, Switzerland), 2023

Role of paraoxonase 1 activity and PON1 gene polymorphisms in sickle cell disease.

Menezes JF et al.

Scientific Reports, 2023

Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.

Boukhalfa W et al.

Frontiers in Aging Neuroscience, 2023

37342358 (PubMed )
Supplement: Table_2.XLSX › Table_2_SNPnexus_annotation

Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study.

Kobayashi S et al.

Reproductive Toxicology (elmsford, N.y.), 2022

Polymorphisms of Cytochromes P450 and Glutathione S-Transferases Synergistically Modulate Risk for Parkinson's Disease.

Fan HH et al.

Frontiers in Aging Neuroscience, 2022

Case report: Two unique nonsense mutations in HTRA1-related cerebral small vessel disease in a Chinese population and literature review.

Chen W et al.

Frontiers in Neurology, 2022

36619910 (PubMed )
Supplement: Data_Sheet_3.ZIP › case-C › 3.________ › CA2245B________.__________________________________.xlsx › sheet1

The Relevance of Noncoding DNA Variations of Paraoxonase Gene Cluster in Atherosclerosis-Related Diseases.

Wysocka A et al.

International Journal of Molecular Sciences, 2021

Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease.

Parween F et al.

Plos One, 2021

WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2.

Carusone TM et al.

Cell Death & Disease, 2020

Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: Genotypic and phenotypic evaluation.

Shokri Y et al.

Diabetes Research and Clinical Practice, 2020

Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression.

Singh R et al.

Plos One, 2020

32492030 (PubMed )
Supplement: pone.0233058.s001.xlsx › RADS28

Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes.

Mahrooz A et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2018

Association of PON2 Gene Polymorphisms (Ser311Cys and Ala148Gly) With the Risk of Developing Type 2 Diabetes Mellitus in the Chinese Population.

Ren H et al.

Frontiers in Endocrinology, 2018

Paraoxonase-2 variants potentially influence insulin resistance, beta-cell function, and their interrelationships with alanine aminotransferase in type 2 diabetes.

Qujeq D et al.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences, 2018

Exome sequencing identifies a novel UNC5D mutation in a severe myopic anisometropia family: A case report.

Feng L et al.

Medicine, 2017

Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.

Park HJ et al.

Journal of Molecular Neuroscience : Mn, 2015

Identification of HPV integration and gene mutation in HeLa cell line by integrated analysis of RNA-Seq and MS/MS data.

Sun H et al.

Journal of Proteome Research, 2015

25698088 (PubMed )
Supplement: pr500944c_si_009.xlsx › SNV

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.

Tang X et al.

Nucleic Acids Research, 2014

25352556 (PubMed )
Supplement: supp_gku1005_nar-01266-met-n-2014-File012.xlsx › TCGA-A8-A06P-01A.domain

Targeted exon capture and sequencing in sporadic amyotrophic lateral sclerosis.

Couthouis J et al.

Plos Genetics, 2014

Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort.

Li S et al.

Journal of Assisted Reproduction and Genetics, 2014

Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy.

Wang J et al.

Molecular Medicine Reports, 2013

Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing.

Kenna KP et al.

Journal of Medical Genetics, 2013

23881933 (PubMed )
Supplement: jmedgenet-2013-101795-s1.pdf

Association of polymorphism of ser311cys paraoxonase-2 gene with type 2 diabetes mellitus in iran.

Andalib S et al.

International Journal of Preventive Medicine, 2013

Association between paraoxonase gene and stroke in the Han Chinese population.

Zhang G et al.

Bmc Medical Genetics, 2013

Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review.

Yuzhalin AE et al.

Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews, 2012

Genes and abdominal aortic aneurysm.

Hinterseher I et al.

Annals of Vascular Surgery, 2011

Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children.

Huen K et al.

Environmental and Molecular Mutagenesis, 2011

Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.

Dasgupta S et al.

Bmc Medical Genetics, 2011

Synergistic effect of polymorphisms of paraoxonase gene cluster and arsenic exposure on electrocardiogram abnormality.

Liao YT et al.

Toxicology and Applied Pharmacology, 2009

Paraoxonase gene polymorphism in south-western Korean population.

Shin BS

Journal of Korean Medical Science, 2009

Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.

Giusti B et al.

Journal of Medical Genetics, 2008

Association of cys 311 ser polymorphism of paraoxonase-2 gene with the risk of coronary artery disease.

Jalilian A et al.

Archives of Iranian Medicine, 2008

Study of the relationship between gene polymorphisms of paraoxonase 2 and stroke in a Chinese population.

Xu HW et al.

Cerebrovascular Diseases (basel, Switzerland), 2008

Genetic contributions to preterm birth: implications from epidemiological and genetic association studies.

Plunkett J et al.

Annals of Medicine, 2008

Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis.

Cronin S et al.

Journal of Neurology, Neurosurgery, and Psychiatry, 2007

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

Harris SE et al.

Bmc Genetics, 2007

17601350 (PubMed )
Supplement: 1471-2156-8-43-S1.doc

[Relationship between single nucleotide polymorphisms of paraoxonase 2 and stroke].

Xu HW et al.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 2007

Interactions and associations of paraoxonase gene cluster polymorphisms with myocardial infarction in a Pakistani population.

Saeed M et al.

Clinical Genetics, 2007

Paraoxonase 2 (PON2) polymorphisms and development of renal dysfunction in type 2 diabetes: UKPDS 76.

Calle R et al.

Diabetologia, 2006

Paraoxonase 1, 2 and 3 DNA variants and susceptibility to childhood inflammatory bowel disease.

Sanchez R et al.

Gut, 2006

Genetic factors for obesity.

Yamada Y et al.

International Journal of Molecular Medicine, 2006

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