Varaico: Literature-Extracted Genetic Variants

Gene:PPARA
Variant:p.L162V
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PPARA

NM_005036.6:p.L162V

Associated Papers

Prognostic and functional role of PPAR-alpha and SNP receptor (Leu162Val) in acute coronary syndrome: a potential novel target.

Raeef AA et al.

Journal, Genetic Engineering & Biotechnology, 2025

Polymorphic Variants of Selected Genes Regulating Bile Acid Homeostasis in Women with Intrahepatic Cholestasis of Pregnancy.

Piątek K et al.

International Journal of Molecular Sciences, 2025

Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease.

Wang JJ et al.

Frontiers in Physiology, 2025

40166716 (PubMed )
Supplement: Table1.xlsx › Table_S1__

Target gene variations of PPAR isoforms may contribute to MODY heterogeneity: A preliminary comparative study with type 2 diabetes.

Yilmaz-Aydogan H et al.

Diabetes Research and Clinical Practice, 2024

Genetic Variants of Obesity in Malaysia: A Scoping Review.

Hamzah SS et al.

Genes, 2024

APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps: A secondary analysis of the seAFOod polyp prevention trial.

Sun G et al.

Prostaglandins, Leukotrienes, and Essential Fatty Acids, 2024

An association between PPARα-L162V polymorphism and increased plasma LDL cholesterol levels after risperidone treatment.

Nadalin S et al.

Prostaglandins, Leukotrienes, and Essential Fatty Acids, 2024

C Allele of the PPARδ+294T>C Polymorphism Confers a Higher Risk of Hypercholesterolemia, but not Obesity and Insulin Resistance: A Systematic Review and Meta-Analysis.

Li S et al.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 2023

Association between Genotype and the Glycemic Response to an Oral Glucose Tolerance Test: A Systematic Review.

Bayer S et al.

Nutrients, 2023

Frequencies of variants in genes associated with dyslipidemias identified in Costa Rican genomes.

Valverde-Hernández JC et al.

Frontiers in Genetics, 2023

Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.

Boukhalfa W et al.

Frontiers in Aging Neuroscience, 2023

37342358 (PubMed )
Supplement: Table_2.XLSX › Table_2_SNPnexus_annotation

Population-based meta-analysis and gene-set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids.

Handelman SK et al.

Hepatology Communications, 2022

36098472 (PubMed )
Supplement: HEP4-6-3120-s001.xlsx › ST6

Metabolic syndrome and underlying genetic determinants-A systematic review.

Rana S et al.

Journal of Diabetes and Metabolic Disorders, 2022

The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome.

Kemanci A et al.

Cureus, 2022

Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts.

Dagli-Hernandez C et al.

Pharmacological Reports : Pr, 2022

Genotype-phenotype correlation in Phelan-McDermid syndrome: A comprehensive review of chromosome 22q13 deleted genes.

Ricciardello A et al.

American Journal of Medical Genetics. Part A, 2021

33949759 (PubMed )
Supplement: AJMG-185-2211-s001.xls › Suppl_Table_S4

Does polymorphisms in PPAR and APOE genes modify associations between fatty acid desaturase (FADS), n-3 long-chain PUFA and cardiometabolic markers in 8-11-year-old Danish children?

Damsgaard CT et al.

The British Journal of Nutrition, 2021

Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.

Aboul-Soud MAM et al.

Saudi Journal of Biological Sciences, 2021

33424349 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Exome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: The Tip of the Iceberg.

Alves-Leon SV et al.

Frontiers in Genetics, 2021

33815474 (PubMed )
Supplement: Table_2.XLSX › Table_XX

Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia.

Wada Y et al.

Ebiomedicine, 2020

33279456 (PubMed )
Supplement: mmc3.pdf

Variants and expression changes in PPAR-encoding genes display no significant association with schizophrenia.

Li X et al.

Bioscience Reports, 2020

Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico.

Carrillo-Venzor MA et al.

Genes, 2020

Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations.

Sprissler R et al.

Cancers, 2020

32570879 (PubMed )
Supplement: cancers-12-01618-s001.zip › cancers-817200-Supplementary_Materials3 › Supplementary_table_S1.xlsx › TSG

Association of common gene-smoking interactions with elevated plasma apolipoprotein B concentration.

Roy N et al.

Lipids in Health and Disease, 2020

Alzheimer's Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α.

Sáez-Orellana F et al.

Cells, 2020

Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.

Saki S et al.

Middle East Journal of Digestive Diseases, 2020

Genetic variants associated with exercise performance in both moderately trained and highly trained individuals.

Harvey NR et al.

Molecular Genetics and Genomics : Mgg, 2020

Heritability and Genetics of Type 2 Diabetes Mellitus in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

Asamoah EA et al.

Journal of Diabetes Research, 2020

32685554 (PubMed )
Supplement: 3198671.f1.pdf

Impact of PPAR-Alpha Polymorphisms-The Case of Metabolic Disorders and Atherosclerosis.

Ruscica M et al.

International Journal of Molecular Sciences, 2019

The Polymorphisms of the Peroxisome-Proliferator Activated Receptors' Alfa Gene Modify the Aerobic Training Induced Changes of Cholesterol and Glucose.

Maciejewska-Skrendo A et al.

Journal of Clinical Medicine, 2019

Targeted next generation sequencing as a tool for precision medicine.

Gulilat M et al.

Bmc Medical Genomics, 2019

31159795 (PubMed )
Supplement: 12920_2019_527_MOESM1_ESM.xlsx › Table_S6

Association between PPARs Gene Functional Polymorphisms and Ischemic Stroke in Chinese Uyghur Population.

Tong Y et al.

The Journal of Nutrition, Health & Aging, 2019

Genetic polymorphisms of PPAR genes and human cancers: evidence for gene-environment interactions.

Dhaini HR et al.

Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews, 2019

The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2nd Trimester Lipid Levels and Preterm Birth.

Kovac U et al.

Frontiers in Genetics, 2019

31249592 (PubMed )
Supplement: Presentation_1.pdf

Significance of genetic polymorphisms in patients with nonalcoholic fatty liver disease.

Miyaaki H et al.

Clinical Journal of Gastroenterology, 2017

Genetic Obesity Risk and Attenuation Effect of Physical Fitness in Mexican-Mestizo Population: a Case-Control Study.

Costa-Urrutia P et al.

Annals of Human Genetics, 2017

The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients.

Nadalin S et al.

Journal of Neural Transmission (vienna, Austria : 1996), 2017

Genetic variation in the 3'-untranslated region of PAK1 influences schizophrenia susceptibility.

Jiang J et al.

Experimental and Therapeutic Medicine, 2017

An association between the PPARα-L162V polymorphism and nicotine dependency among patients with schizophrenia.

Nadalin S et al.

Comprehensive Psychiatry, 2016

The association of peroxisome proliferator-activated receptor α with diabetic retinopathy, and additional gene-obesity interaction in Chinese type 2 diabetes mellitus patients.

Qi S et al.

Obesity Research & Clinical Practice, 2016

Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.

Ke T et al.

Annals of Human Genetics, 2016

Genetics of nonalcoholic fatty liver disease.

Dongiovanni P et al.

Metabolism: Clinical and Experimental, 2016

Association between peroxisome proliferator-activated receptor-alpha, delta, and gamma polymorphisms and risk of coronary heart disease: A case-control study and meta-analysis.

Qian Y et al.

Medicine, 2016

Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.

Yang Y et al.

Endocrine Reviews, 2016

Functional Genetic Variants of PPARx03B3; and PPARα Encoding Peroxisome Proliferator-Activated Receptors and Susceptibility to Ischemic Stroke in Chinese Han Population.

Tong Y et al.

Cerebrovascular Diseases (basel, Switzerland), 2016

Screening of Peroxisome Proliferator-Activated Receptors (PPARs) α, γ and α Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-Ethnic Malaysian Population.

Chia PP et al.

Ethnicity & Disease, 2015

Donor PPARα Gene Polymorphisms Influence the Susceptibility to Glucose and Lipid Disorders in Liver Transplant Recipients: A Strobe-Compliant Observational Study.

Ling Q et al.

Medicine, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."