Associated Papers
Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres.
Storchova R et al.
Nucleic Acids Research, 2023
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Miller PG et al.
Nature Communications, 2022
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
Khadka P et al.
Nature Communications, 2022
A novel assay for screening WIP1 phosphatase substrates in nuclear extracts.
Storchova R et al.
The Febs Journal, 2021
Wip1 regulates Smad4 phosphorylation and inhibits TGF-β signaling.
Park DS et al.
Embo Reports, 2020
WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation.
Choi BK et al.
Cell Cycle (georgetown, Tex.), 2020
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Fons NR et al.
Nature Communications, 2019
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Hsu JI et al.
Cell Stem Cell, 2018
LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.
Wamsley JJ et al.
Cell Cycle (georgetown, Tex.), 2017
PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.
Zhang M et al.
Oncogene, 2015
PPM1D regulates p21 expression via dephoshporylation at serine 123.
Cao R et al.
Cell Cycle (georgetown, Tex.), 2015
DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.
Brazina J et al.
Cell Cycle (georgetown, Tex.), 2015
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
Zhang L et al.
Nature Genetics, 2014
Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity.
Tanoue K et al.
Biochemistry, 2013
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.
Kleiblova P et al.
The Journal of Cell Biology, 2013
Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.
Macurek L et al.
Cell Cycle (georgetown, Tex.), 2013
Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.
Dayaram T et al.
Plos One, 2013
Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition.
Kalev P et al.
Cancer Research, 2012
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation.
Xia Y et al.
The International Journal of Biochemistry & Cell Biology, 2011
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
Nguyen TA et al.
Dna Repair, 2010
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Moon SH et al.
The Journal of Biological Chemistry, 2010
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Macůrek L et al.
Oncogene, 2010
Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.
Lindqvist A et al.
The Embo Journal, 2009
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Lu X et al.
Cancer Cell, 2007
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.
Oliva-Trastoy M et al.
Oncogene, 2007
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Shreeram S et al.
Molecular Cell, 2006
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.
Fujimoto H et al.
Cell Death and Differentiation, 2006