Associated Papers
PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease.
Chiang CY et al.
Cell Reports, 2025
Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
Dhekne HS et al.
Elife, 2023
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.
Dou D et al.
Cell Reports, 2023
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.
Waschbüsch D et al.
Embo Reports, 2021
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Malik AU et al.
The Biochemical Journal, 2021
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.
Berndsen K et al.
Elife, 2019
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