Varaico: Literature-Extracted Genetic Variants

Gene:PPP2R1A
Variant:p.R183G
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PPP2R1A

NM_014225.6:p.R183G

Associated Papers

PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma.

Stewart J et al.

Oncogene, 2025

39939726 (PubMed )
Supplement: 41388_2024_3265_MOESM2_ESM.xlsx › Sheet1

The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs).

Zhang L et al.

Elife, 2024

39688960 (PubMed )
Supplement: elife-99340-supp1.xlsx › CDN.Missense.gnomad

Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients.

Qian Y et al.

Genes, 2023

Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.

Ghezelayagh TS et al.

Cancer Research Communications, 2022

36311816 (PubMed )
Supplement: crc-22-0314-s02.xlsx › Table_S6_List_of_mutations

Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

White JA et al.

Cancer Research Communications, 2022

36922933 (PubMed )
Supplement: crc-22-0136-s01.xlsx › ST3_Known_Somatic_Variants

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors.

O'Connor CM et al.

Oncogene, 2020

Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.

Haesen D et al.

Cancer Research, 2016

HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function.

Nobumori Y et al.

The Journal of Biological Chemistry, 2012

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Jones S et al.

Science (new York, N.y.), 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."