Varaico: Literature-Extracted Genetic Variants

Gene:PPP2R1A
Variant:p.W257C
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PPP2R1A

NM_014225.6:p.W257C

Associated Papers

A Subset of Serous Tubal Intraepithelial Carcinoma (STIC)-Like Lesions and Concurrent High-Grade Endometrial Carcinoma Are Genomically Related Entities.

da Silva EM et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2025

Prenatal Characterization of Houge-Janssens Syndrome Type 2: A Case Report and Systematic Review of Fetal Phenotypes Associated With PPP2R1A Mutations.

Hu J et al.

Molecular Genetics & Genomic Medicine, 2025

Oncogenic composite mutations can be predicted by co-mutations and their chromosomal location.

Küçükosmanoglu A et al.

Molecular Oncology, 2024

38757376 (PubMed )
Supplement: MOL2-18-2407-s001.xlsx › 1E_Excluded_datasets

PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell Complex.

Wang Y et al.

Nature Communications, 2023

Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.

Ghezelayagh TS et al.

Cancer Research Communications, 2022

36311816 (PubMed )
Supplement: crc-22-0314-s02.xlsx › Table_S6_List_of_mutations

Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study.

Aoyagi Y et al.

Plos One, 2022

35358259 (PubMed )
Supplement: pone.0266112.s001.xlsx › Patients

Clinical implications of plasma circulating tumor DNA in gynecologic cancer patients.

Charo LM et al.

Molecular Oncology, 2021

32881280 (PubMed )
Supplement: MOL2-15-67-s001.docx

Integrated Somatic and Germline Whole-Exome Sequencing Analysis in Women with Lung Cancer after a Previous Breast Cancer.

Coco S et al.

Cancers, 2019

30925779 (PubMed )
Supplement: cancers-11-00441-s001.zip › cancers-452240-Supplementary › Table_S5.xlsx › Table_S5

Copy number signatures and mutational processes in ovarian carcinoma.

Macintyre G et al.

Nature Genetics, 2018

30104763 (PubMed )
Supplement: NIHMS78219-supplement-3.xlsx › mutated_cases

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium.

Suda K et al.

Cell Reports, 2018

Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.

Haesen D et al.

Cancer Research, 2016

Lavage of the Uterine Cavity for Molecular Detection of Müllerian Duct Carcinomas: A Proof-of-Concept Study.

Maritschnegg E et al.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2015

Targeted mutation analysis of endometrial clear cell carcinoma.

Hoang LN et al.

Histopathology, 2015

Frequent POLE1 p.S297F mutation in Chinese patients with ovarian endometrioid carcinoma.

Zou Y et al.

Mutation Research, 2014

Infrequent mutations of the PPP2R1A and PPP2R1B genes in patients with ovarian cancer.

Wang F et al.

Molecular Medicine Reports, 2013

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.

Le Gallo M et al.

Nature Genetics, 2012

23104009 (PubMed )
Supplement: NIHMS412622-supplement-4.xls › Supplementary_Table_5

PPP2R1A mutations are common in the serous type of endometrial cancer.

Nagendra DC et al.

Molecular Carcinogenesis, 2012

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.

McConechy MK et al.

The Journal of Pathology, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."