Associated Papers
Inducible Protein Degradation as a Strategy to Identify Phosphoprotein Phosphatase 6 Substrates in RAS-Mutant Colorectal Cancer Cells.
Mariano NC et al.
Molecular & Cellular Proteomics : Mcp, 2023
PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death.
Wu G et al.
Cell Death & Disease, 2022
Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
Zou Y et al.
Cell Death & Disease, 2022
Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.
Lei WL et al.
Cell Death & Disease, 2021
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
Cho E et al.
Cell Reports, 2021
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
Wengrod J et al.
Science Signaling, 2015
Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks.
Zhong J et al.
Cell Cycle (georgetown, Tex.), 2011
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