Associated Papers
Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy.
Kozul KL et al.
Research Square, 2026
PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy.
Xu X et al.
Cell Death & Disease, 2025
PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.
Niemi NM et al.
Nature Communications, 2023
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