Associated Papers
Understanding P-Rex regulation: structural breakthroughs and emerging perspectives.
Jones GD et al.
Biochemical Society Transactions, 2024
Tumorigenesis driven by the BRAFV600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion.
Gadal S et al.
Biorxiv : the Preprint Server for Biology, 2024
Tumor genomic profiling and personalized tracking of circulating tumor DNA in Vietnamese colorectal cancer patients.
Nguyen HT et al.
Frontiers in Oncology, 2022
36578946 (PubMed )
Supplement: DataSheet_2.xlsx › Variants_detected_in_FFPE
Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.
D'Andrea L et al.
Science Signaling, 2021
RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.
Lionarons DA et al.
Cancer Cell, 2019
P-Rex1 and P-Rex2 RacGEFs and cancer.
Srijakotre N et al.
Biochemical Society Transactions, 2017
Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations.
Horrigan SK et al.
Elife, 2017
Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma.
Lissanu Deribe Y
Small Gtpases, 2016
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Lissanu Deribe Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016
Melanoma genome sequencing reveals frequent PREX2 mutations.
Berger MF et al.
Nature, 2012
Select a paper to view details