Varaico: Literature-Extracted Genetic Variants

Gene:PRKAA2
Variant:p.D157A
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PRKAA2

NM_006252.4:p.D157A

Associated Papers

GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer.

McKinney AM et al.

Cell Reports, 2022

The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition.

Queiroz AL et al.

Molecular Metabolism, 2021

l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism.

Adachi Y et al.

Molecular Metabolism, 2018

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.

Fogarty S et al.

Molecular Cancer Research : Mcr, 2016

Suppression of B-Raf(V600E) cancers by MAPK hyper-activation.

Atiq R et al.

Oncotarget, 2016

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.

Wiley CD et al.

Cell Metabolism, 2016

A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress.

Ritho J et al.

Cell Reports, 2015

The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation.

Oligschlaeger Y et al.

The Journal of Biological Chemistry, 2015

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

Hawley SA et al.

The Biochemical Journal, 2014

Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase.

King JD et al.

The Journal of Biological Chemistry, 2012

Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.

Romá-Mateo C et al.

The Biochemical Journal, 2011

Functional modulation of AMP-activated protein kinase by cereblon.

Lee KM et al.

Biochimica Et Biophysica Acta, 2011

AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.

King JD et al.

American Journal of Physiology. Cell Physiology, 2009

Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle.

Garcia-Roves PM et al.

The Journal of Biological Chemistry, 2008

Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway.

Solaz-Fuster MC et al.

Human Molecular Genetics, 2008

Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.

Neumann D et al.

Molecular Biotechnology, 2007

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.

Bhalla V et al.

The Journal of Biological Chemistry, 2006

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells.

Carattino MD et al.

The Journal of Biological Chemistry, 2005

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.

Woods A et al.

The Journal of Biological Chemistry, 2003

The regulation of AMP-activated protein kinase by phosphorylation.

Stein SC et al.

The Biochemical Journal, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."