Varaico: Literature-Extracted Genetic Variants

Gene:PRKAA2
Variant:p.T172A
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PRKAA2

NM_006252.4:p.T172A

Associated Papers

AMPKα2 signals amino acid insufficiency to inhibit protein synthesis.

Mao Y et al.

Cell Metabolism, 2026

The metabolic sensor AMPK: Twelve enzymes in one.

Smiles WJ et al.

Molecular Metabolism, 2024

CTRP13-Mediated Effects on Endothelial Cell Function and Their Potential Role in Obesity.

Aslam M et al.

Cells, 2024

Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy.

Zaninello M et al.

Cell Death and Differentiation, 2022

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy.

Zaninello M et al.

Nature Communications, 2020

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation.

Gong H et al.

Frontiers in Immunology, 2020

Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation.

Zhang S et al.

Cell Death & Disease, 2019

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA et al.

Nature Communications, 2017

Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.

Mo C et al.

Journal of Hypertension, 2017

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.

Dey P et al.

Nature, 2017

AMPK activation by GSK621 inhibits human melanoma cells in vitro and in vivo.

Chen L et al.

Biochemical and Biophysical Research Communications, 2016

AMPK modulates Hippo pathway activity to regulate energy homeostasis.

Wang W et al.

Nature Cell Biology, 2015

AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.

Kemmerer M et al.

Plos One, 2015

Characterization of the CaMKKβ-AMPK signaling complex.

Green MF et al.

Cellular Signalling, 2011

The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ et al.

Cancer Cell, 2004

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

Hawley SA et al.

Journal of Biology, 2003

The regulation of AMP-activated protein kinase by phosphorylation.

Stein SC et al.

The Biochemical Journal, 2000

Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.

Crute BE et al.

The Journal of Biological Chemistry, 1998

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."