Varaico: Literature-Extracted Genetic Variants

Gene:PRKCA
Variant:p.A25E
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PRKCA

NM_002737.3:p.A25E

Associated Papers

A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring.

Bellamy C et al.

Biorxiv : the Preprint Server for Biology, 2025

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactions.

Jehle S et al.

Molecular Systems Biology, 2022

A New Mouse Model Related to SCA14 Carrying a Pseudosubstrate Domain Mutation in PKCγ Shows Perturbed Purkinje Cell Maturation and Ataxic Motor Behavior.

Shimobayashi E et al.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2021

PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling.

Yang S et al.

Science Signaling, 2020

The PKC gene module: molecular biosystematics to resolve its T cell functions.

Baier G

Immunological Reviews, 2003

Regulation of retinoid X receptor responsive element-dependent transcription in T lymphocytes by Ser/Thr phosphatases: functional divergence of protein kinase C (PKC)theta; and PKC alpha in mediating calcineurin-induced transactivation.

Ishaq M et al.

Journal of Immunology (baltimore, Md. : 1950), 2002

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes.

Baier-Bitterlich G et al.

Molecular and Cellular Biology, 1996

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."