Associated Papers
Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions.
Li Y et al.
Medcomm, 2025
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.
Gauron MC et al.
Science Signaling, 2025
Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance.
Gauron MC et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.
Jones AC et al.
The Biochemical Journal, 2023
Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.
Jones AC et al.
Biorxiv : the Preprint Server for Biology, 2023
Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.
Lordén G et al.
Nature Communications, 2022
Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?
Lordén G et al.
Neuronal Signaling, 2021
Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.
Callender JA et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.
Alfonso SI et al.
Science Signaling, 2016
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