Varaico: Literature-Extracted Genetic Variants

Gene:PRKCB
Variant:p.S660A
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PRKCB

NM_002738.7:p.S660A

Associated Papers

PKCβII activation requires nuclear trafficking for phosphorylation and Mdm2-mediated ubiquitination.

Min X et al.

Life Science Alliance, 2023

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Baffi TR et al.

Science Signaling, 2021

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Baffi TR et al.

Molecular Cell, 2019

Novel Features of DAG-Activated PKC Isozymes Reveal a Conserved 3-D Architecture.

Lučić I et al.

Journal of Molecular Biology, 2016

Identification of acidic amino acid residues in the protein kinase C alpha V5 domain that contribute to its insensitivity to diacylglycerol.

Stensman H et al.

The Journal of Biological Chemistry, 2007

Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII.

Edwards AS et al.

The Journal of Biological Chemistry, 1999

Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C.

Edwards AS et al.

The Journal of Biological Chemistry, 1997

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."