Associated Papers
Human DNA-dependent protein kinase catalytic subunit deficiency: A comprehensive review and update.
Adelon J et al.
The Journal of Allergy and Clinical Immunology, 2024
DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells.
Hristova DB et al.
Iscience, 2024
Structural analysis of the basal state of the Artemis:DNA-PKcs complex.
Watanabe G et al.
Nucleic Acids Research, 2022
Physical ARTEMIS:DNA-PKcs interaction is necessary for V(D)J recombination.
Niewolik D et al.
Nucleic Acids Research, 2022
Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.
Lees-Miller JP et al.
Progress in Biophysics and Molecular Biology, 2021
DNA-Dependent Protein Kinase Catalytic Subunit: The Sensor for DNA Double-Strand Breaks Structurally and Functionally Related to Ataxia Telangiectasia Mutated.
Matsumoto Y et al.
Genes, 2021
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy.
Ye Z et al.
Frontiers in Immunology, 2021
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.
Sun X et al.
Nature Communications, 2020
DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.
Anne Esguerra Z et al.
Molecular Immunology, 2020
ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition ≠ deletion.
Menolfi D et al.
Cell & Bioscience, 2020
Two siblings with PRKDC defect who presented with cutaneous granulomas and review of the literature.
Esenboga S et al.
Clinical Immunology (orlando, Fla.), 2018
Newly recognized Mendelian disorders with rheumatic manifestations.
de Jesus AA et al.
Current Opinion in Rheumatology, 2015
PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.
Mathieu AL et al.
The Journal of Allergy and Clinical Immunology, 2015
Congenital defects in V(D)J recombination.
de Villartay JP
British Medical Bulletin, 2015
The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.
Li M et al.
Free Radical Biology & Medicine, 2014
DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.
Lin YF et al.
Nucleic Acids Research, 2014
DNA double strand break repair via non-homologous end-joining.
Davis AJ et al.
Translational Cancer Research, 2013
Diseases associated with defective responses to DNA damage.
O'Driscoll M
Cold Spring Harbor Perspectives in Biology, 2012
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
Malewicz M et al.
Genes & Development, 2011
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum.
Abbaszadeh F et al.
Journal of Medical Genetics, 2010
Radiosensitive severe combined immunodeficiency disease.
Dvorak CC et al.
Immunology and Allergy Clinics of North America, 2010
DNA-PKcs deficiency in human: long predicted, finally found.
van der Burg M et al.
Current Opinion in Allergy and Clinical Immunology, 2009
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.
van der Burg M et al.
The Journal of Clinical Investigation, 2009