Associated Papers
Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice.
Zhu Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
The recent advances in non-homologous end-joining through the lens of lymphocyte development.
Wang XS et al.
Dna Repair, 2020
ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition ≠ deletion.
Menolfi D et al.
Cell & Bioscience, 2020
Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.
Zhang S et al.
Oncogene, 2016
Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity.
Cartwright IM et al.
Oncology Letters, 2015
Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.
Lin YF et al.
Plos One, 2014
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
Zhou Y et al.
The Journal of Biological Chemistry, 2013
Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.
Javvadi P et al.
Molecular Cancer Research : Mcr, 2012
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence.
Williams ES et al.
Cancer Research, 2009
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
Chen BP et al.
The Journal of Biological Chemistry, 2007
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends.
Block WD et al.
Nucleic Acids Research, 2004
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.
Chan DW et al.
Genes & Development, 2002
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