Associated Papers
Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase.
Fiesel FC et al.
Autophagy, 2025
Computational Study of the Activation Mechanism of Wild-Type Parkin and Its Clinically Relevant Mutant.
Cinviz ZN et al.
Acs Chemical Neuroscience, 2025
Therapeutic potential of Parkin and its regulation in Parkinson's disease.
Safreena N et al.
Biochemical Pharmacology, 2024
In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling.
Islam NN et al.
Biomolecules, 2024
Structure-based design and characterization of Parkin-activating mutations.
Stevens MU et al.
Life Science Alliance, 2023
Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration.
González-Casacuberta I et al.
Frontiers in Neuroscience, 2019
Structure of the human Parkin ligase domain in an autoinhibited state.
Wauer T et al.
The Embo Journal, 2013
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