Associated Papers
Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study.
Westenberger A et al.
Brain : a Journal of Neurology, 2024
Structure-based design and characterization of Parkin-activating mutations.
Stevens MU et al.
Life Science Alliance, 2023
Assessing the relationship between monoallelic PRKN mutations and Parkinson's risk.
Lubbe SJ et al.
Human Molecular Genetics, 2021
Dysfunction of Synaptic Vesicle Endocytosis in Parkinson's Disease.
Zou L et al.
Frontiers in Integrative Neuroscience, 2021
Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration.
González-Casacuberta I et al.
Frontiers in Neuroscience, 2019
UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN.
Park S et al.
The Journal of Biological Chemistry, 2017
Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder.
Yin CL et al.
Molecular Autism, 2016
Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria.
Koyano F et al.
Biochimica Et Biophysica Acta, 2015
Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.
Fiesel FC et al.
Human Mutation, 2015
Parkin Is Dispensable for Mitochondrial Function, but Its Ubiquitin Ligase Activity Is Critical for Macroautophagy and Neurotransmitters: Therapeutic Potential beyond Parkinson's Disease.
Moussa CE
Neuro-degenerative Diseases, 2015
Genetic insights into sporadic Parkinson's disease pathogenesis.
Chai C et al.
Current Genomics, 2013
Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson's Disease.
Oczkowska A et al.
Current Genomics, 2013
Structure of the human Parkin ligase domain in an autoinhibited state.
Wauer T et al.
The Embo Journal, 2013
Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase.
Byrd RA et al.
The Embo Journal, 2013
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases.
Riley BE et al.
Nature Communications, 2013
Phenotype analysis in patients with early onset Parkinson's disease with and without parkin mutations.
Kim HJ et al.
Journal of Neurology, 2011
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.
Nuytemans K et al.
Human Mutation, 2010
Identification and characterization of a novel endogenous murine parkin mutation.
Ramsey CP et al.
Journal of Neurochemistry, 2010
Parkin-associated Parkinson's disease.
von Coelln R et al.
Cell and Tissue Research, 2004
Parkin genetics: one model for Parkinson's disease.
Mata IF et al.
Human Molecular Genetics, 2004
Parkin mutations are frequent in patients with isolated early-onset parkinsonism.
Periquet M et al.
Brain : a Journal of Neurology, 2003