Varaico: Literature-Extracted Genetic Variants

Gene:PRKN
Variant:p.V393D
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PRKN

NM_004562.3:p.V393D

Associated Papers

Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase.

Fiesel FC et al.

Autophagy, 2025

Computational Study of the Activation Mechanism of Wild-Type Parkin and Its Clinically Relevant Mutant.

Cinviz ZN et al.

Acs Chemical Neuroscience, 2025

Therapeutic potential of Parkin and its regulation in Parkinson's disease.

Safreena N et al.

Biochemical Pharmacology, 2024

In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling.

Islam NN et al.

Biomolecules, 2024

Structure-based design and characterization of Parkin-activating mutations.

Stevens MU et al.

Life Science Alliance, 2023

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."