Associated Papers
Cis or trans: a puzzle of Parkin activation mechanism.
Sherawat M et al.
Essays in Biochemistry, 2026
Expanding the utility of variant effect predictions with phenotype-specific models.
Stein D et al.
Nature Communications, 2025
The novel protein SEMA3C-319aa triggers glutathione metabolism-dependent ferroptosis in gastric cancer.
Xiao S et al.
Oncogene, 2025
Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson's Disease.
Flores-Ocampo V et al.
Genes, 2025
Glutathione S-transferase: A keystone in Parkinson's disease pathogenesis and therapy.
Padhan P et al.
Molecular and Cellular Neurosciences, 2025
SFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin.
Luo S et al.
Frontiers in Cellular Neuroscience, 2025
Therapeutic potential of Parkin and its regulation in Parkinson's disease.
Safreena N et al.
Biochemical Pharmacology, 2024
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture.
Ma Q et al.
Embo Reports, 2023
Two Different PRKN Compound Heterozygous Variants Combinations in the Same Family.
Biehler M et al.
Movement Disorders Clinical Practice, 2023
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease.
Tang W et al.
Human Molecular Genetics, 2023
Post-translational modification and mitochondrial function in Parkinson's disease.
Luo S et al.
Frontiers in Molecular Neuroscience, 2023
The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy.
Sun S et al.
The Journal of Biological Chemistry, 2022
Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson's Disease.
Kim J et al.
Genes, 2022
Structural basis for feedforward control in the PINK1/Parkin pathway.
Sauvé V et al.
The Embo Journal, 2022
The Role of NEDD4 E3 Ubiquitin-Protein Ligases in Parkinson's Disease.
Conway JA et al.
Genes, 2022
Comparative analysis of web-based programs for single amino acid substitutions in proteins.
Choudhury A et al.
Plos One, 2022
Animal Models of Autosomal Recessive Parkinsonism.
Bastioli G et al.
Biomedicines, 2021
Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse.
Regoni M et al.
Biomedicines, 2021
Assessing the relationship between monoallelic PRKN mutations and Parkinson's risk.
Lubbe SJ et al.
Human Molecular Genetics, 2021
The Role of VPS35 in the Pathobiology of Parkinson's Disease.
Sassone J et al.
Cellular and Molecular Neurobiology, 2021
Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease.
Kamienieva I et al.
Translational Neurodegeneration, 2021
Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal Models.
Kee TR et al.
Frontiers in Aging Neuroscience, 2021
Pluripotent Stem Cell Derived Neurons as In Vitro Models for Studying Autosomal Recessive Parkinson's Disease (ARPD): PLA2G6 and Other Gene Loci.
Gopurappilly R
Advances in Experimental Medicine and Biology, 2021
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.
Quinn PMJ et al.
Acta Neuropathologica Communications, 2020
Identification of pathogenic missense mutations using protein stability predictors.
Gerasimavicius L et al.
Scientific Reports, 2020
Chaperones and Proteostasis: Role in Parkinson's Disease.
Joshi N et al.
Diseases (basel, Switzerland), 2020
Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles.
Ryan TA et al.
The Embo Journal, 2020
Unraveling correlative roles of dopamine transporter (DAT) and Parkin in Parkinson's disease (PD) - A road to discovery?
Jayaramayya K et al.
Brain Research Bulletin, 2020
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons.
Evans CS et al.
Elife, 2020
Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells.
Tran J et al.
Npj Parkinson's Disease, 2020
The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease.
Yi W et al.
Human Molecular Genetics, 2019
Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?
Calogero AM et al.
Biological Chemistry, 2019
Genetically engineered animal models of Parkinson's disease: From worm to rodent.
Breger LS et al.
The European Journal of Neuroscience, 2019
Miro proteins prime mitochondria for Parkin translocation and mitophagy.
Safiulina D et al.
The Embo Journal, 2019
Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration.
González-Casacuberta I et al.
Frontiers in Neuroscience, 2019
Novel Compound Heterozygous PRKN Variants in a Han-Chinese Family with Early-Onset Parkinson's Disease.
Fan K et al.
Parkinson's Disease, 2019
High-frequency actionable pathogenic exome variants in an average-risk cohort.
Rego S et al.
Cold Spring Harbor Molecular Case Studies, 2018
Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Williams ET et al.
Human Molecular Genetics, 2018
Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin.
Aguirre JD et al.
The Journal of Biological Chemistry, 2018
The M458L missense mutation disrupts the catalytic properties of Parkin.
Do YJ et al.
Febs Letters, 2018
A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders.
George AJ et al.
Frontiers in Genetics, 2018
Linking Glycation and Glycosylation With Inflammation and Mitochondrial Dysfunction in Parkinson's Disease.
Videira PAQ et al.
Frontiers in Neuroscience, 2018
Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.
Zhang C et al.
The Journal of Biological Chemistry, 2017