Associated Papers
Cis or trans: a puzzle of Parkin activation mechanism.
Sherawat M et al.
Essays in Biochemistry, 2026
The Juvenile Parkinson's Disease Mutation C212Y Impairs Mitochondrial Homeostasis in a Caenorhabditis elegans Model.
Spector E et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2025
Computational association in parkinson's disease SNPs with brain structural and functional alterations.
Subramaniyan S et al.
Neurogenetics, 2025
Targeting mitophagy in neurodegenerative diseases.
Antico O et al.
Nature Reviews. Drug Discovery, 2025
Therapeutic potential of Parkin and its regulation in Parkinson's disease.
Safreena N et al.
Biochemical Pharmacology, 2024
Activation of parkin by a molecular glue.
Sauvé V et al.
Nature Communications, 2024
Naturally occurring hyperactive variants of human parkin.
Huq TS et al.
Communications Biology, 2024
Pathogenesis of Parkinson's disease: from hints from monogenic familial PD to biomarkers.
Hattori N et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2024
PRKN-linked familial Parkinson's disease: cellular and molecular mechanisms of disease-linked variants.
Clausen L et al.
Cellular and Molecular Life Sciences : Cmls, 2024
A mutational atlas for Parkin proteostasis.
Clausen L et al.
Nature Communications, 2024
Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2.
Zanon A et al.
Journal of Translational Medicine, 2024
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture.
Ma Q et al.
Embo Reports, 2023
Structural Mechanisms of Mitochondrial Quality Control Mediated by PINK1 and Parkin.
Trempe JF et al.
Journal of Molecular Biology, 2023
Structure-based design and characterization of Parkin-activating mutations.
Stevens MU et al.
Life Science Alliance, 2023
Mitochondrial quality control in health and in Parkinson's disease.
Eldeeb MA et al.
Physiological Reviews, 2022
Therapeutic targeting of mitophagy in Parkinson's disease.
Masaldan S et al.
Biochemical Society Transactions, 2022
The Role of NEDD4 E3 Ubiquitin-Protein Ligases in Parkinson's Disease.
Conway JA et al.
Genes, 2022
Comparative analysis of web-based programs for single amino acid substitutions in proteins.
Choudhury A et al.
Plos One, 2022
AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy.
Hung CM et al.
Science Advances, 2021
Assessing the relationship between monoallelic PRKN mutations and Parkinson's risk.
Lubbe SJ et al.
Human Molecular Genetics, 2021
Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease.
Kamienieva I et al.
Translational Neurodegeneration, 2021
PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson's Disease.
Li W et al.
Frontiers in Cell and Developmental Biology, 2021
Identification of pathogenic missense mutations using protein stability predictors.
Gerasimavicius L et al.
Scientific Reports, 2020
The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease.
Yi W et al.
Human Molecular Genetics, 2019
Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?
Calogero AM et al.
Biological Chemistry, 2019
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set.
Del-Toro N et al.
Nature Communications, 2019
Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration.
González-Casacuberta I et al.
Frontiers in Neuroscience, 2019
Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
Condos TE et al.
The Embo Journal, 2018
Mechanism of parkin activation by phosphorylation.
Sauvé V et al.
Nature Structural & Molecular Biology, 2018
Building and decoding ubiquitin chains for mitophagy.
Harper JW et al.
Nature Reviews. Molecular Cell Biology, 2018
The M458L missense mutation disrupts the catalytic properties of Parkin.
Do YJ et al.
Febs Letters, 2018
A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders.
George AJ et al.
Frontiers in Genetics, 2018
The Transcription Factor Function of Parkin: Breaking the Dogma.
Alves da Costa C et al.
Frontiers in Neuroscience, 2018
Twenty years since the discovery of the parkin gene.
Hattori N et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2017
Dual Function of Phosphoubiquitin in E3 Activation of Parkin.
Walinda E et al.
The Journal of Biological Chemistry, 2016
Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation.
Pao KC et al.
Nature Chemical Biology, 2016
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
Yamano K et al.
Embo Reports, 2016
Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10.
Bertolin G et al.
Cell Death and Differentiation, 2015
Mechanism of phospho-ubiquitin-induced PARKIN activation.
Wauer T et al.
Nature, 2015
Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.
Fiesel FC et al.
Human Mutation, 2015
The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway.
Gao F et al.
Human Molecular Genetics, 2015
Activation of the E3 ubiquitin ligase Parkin.
Caulfield TR et al.
Biochemical Society Transactions, 2015
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Ordureau A et al.
Molecular Cell, 2014
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Bingol B et al.
Nature, 2014
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
Choubey V et al.
Autophagy, 2014