Associated Papers
Targeting mitophagy in neurodegenerative diseases.
Antico O et al.
Nature Reviews. Drug Discovery, 2025
Mechanism of phospho-Ubls' specificity and conformational changes that regulate Parkin activity.
Lenka DR et al.
Structure (london, England : 1993), 2024
Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models.
Han R et al.
The Journal of Clinical Investigation, 2024
Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.
Lenka DR et al.
Elife, 2024
Structural Mechanisms of Mitochondrial Quality Control Mediated by PINK1 and Parkin.
Trempe JF et al.
Journal of Molecular Biology, 2023
Systematic Functional Analysis of PINK1 and PRKN Coding Variants.
Broadway BJ et al.
Cells, 2022
Structural basis for feedforward control in the PINK1/Parkin pathway.
Sauvé V et al.
The Embo Journal, 2022
35491809 (PubMed )
Supplement: EMBJ-41-e109460-s002.pdf
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Antico O et al.
Science Advances, 2021
A model combining clinical and genomic factors to predict response to PD-1/PD-L1 blockade in advanced urothelial carcinoma.
Nassar AH et al.
British Journal of Cancer, 2020
31857723 (PubMed )
Supplement: 41416_2019_686_MOESM1_ESM.xlsx › S2.2_Overall_SNV_small_indels
Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond.
Bayne AN et al.
Cellular and Molecular Life Sciences : Cmls, 2019
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
McWilliams TG et al.
Open Biology, 2018
Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations.
Kumru H et al.
Annals of Neurology, 2004
Select a paper to view details