Associated Papers
The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth.
Cai Z et al.
Neural Regeneration Research, 2026
The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.
Liu Y et al.
Cell Death and Differentiation, 2026
The VvPUB8-VvbHLH93-VvMYB15/VvMYB5a module inhibits the synthesis of anthocyanins in grape in response to MeJA.
Xu X et al.
Journal of Integrative Plant Biology, 2026
The novel protein SEMA3C-319aa triggers glutathione metabolism-dependent ferroptosis in gastric cancer.
Xiao S et al.
Oncogene, 2025
Inactivation of SIAH-1 E3 ligase attenuates Aβ toxicity by suppressing ubiquitin-dependent DVE-1 degradation in Caenorhabditis elegans models of Alzheimer's disease.
Sun L et al.
The Journal of Biological Chemistry, 2025
RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens.
Wang J et al.
Journal of Virology, 2025
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Li W et al.
The Embo Journal, 2025
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.
Gottemukkala KV et al.
Molecular Cell, 2024
E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα.
Yu J et al.
Cell Communication and Signaling : Ccs, 2024
The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis.
Liu S et al.
Cell Discovery, 2024
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs.
Yang S et al.
Molecular Cell, 2024
Zebrafish spop promotes ubiquitination and degradation of mavs to suppress antiviral response via the lysosomal pathway.
Yu GQ et al.
International Journal of Biological Macromolecules, 2024
Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer.
Li J et al.
Science Translational Medicine, 2023
The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation.
Zhu Y et al.
Acta Pharmaceutica Sinica. B, 2023
RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
Liu W et al.
Cell Reports, 2023
P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease.
Kumarasinghe L et al.
Neurobiology of Disease, 2023
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy.
Wang YT et al.
Cell Reports, 2022
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.
Zhang L et al.
Cell Reports, 2021
Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
Guo Y et al.
Cell Death & Disease, 2021
TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Fan W et al.
Cell, 2021
Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.
Wu K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I et al.
Molecular Cell, 2021
Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination.
Langerová H et al.
Cells, 2020
Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.
Yamano K et al.
The Journal of Cell Biology, 2020
SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response.
Li Q et al.
Plos Pathogens, 2020
USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
Niu K et al.
Autophagy, 2020
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome.
Lee SB et al.
Nature Cell Biology, 2019
Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.
Koyano F et al.
The Journal of Biological Chemistry, 2019
Building and decoding ubiquitin chains for mitophagy.
Harper JW et al.
Nature Reviews. Molecular Cell Biology, 2018
UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN.
Park S et al.
The Journal of Biological Chemistry, 2017
Ubiquitination of stalled ribosome triggers ribosome-associated quality control.
Matsuo Y et al.
Nature Communications, 2017
Parkin promotes proteasomal degradation of synaptotagmin IV by accelerating polyubiquitination.
Kabayama H et al.
Molecular and Cellular Neurosciences, 2017
TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
Wang X et al.
The Journal of Biological Chemistry, 2015
A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.
Wang Y et al.
The Journal of Biological Chemistry, 2015
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
Norris KL et al.
The Journal of Biological Chemistry, 2015
The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling.
Chakraborty A et al.
Nature Communications, 2015
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Durcan TM et al.
The Embo Journal, 2014
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.
Birsa N et al.
The Journal of Biological Chemistry, 2014
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA et al.
Nature, 2013
Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration.
Sul JW et al.
Human Molecular Genetics, 2013
The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity.
Qi J et al.
Cancer Cell, 2013
A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
Singer AU et al.
Plos Pathogens, 2013
Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase.
Wang X et al.
Nature Communications, 2013
Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.
Lim GG et al.
Plos One, 2013