Associated Papers
Cis or trans: a puzzle of Parkin activation mechanism.
Sherawat M et al.
Essays in Biochemistry, 2026
Canonical and alternate mechanisms that regulate ubiquitylation by the E3 ligase parkin.
Basilone NT et al.
Biochemical Society Transactions, 2025
Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.
Liu JY et al.
Human Molecular Genetics, 2022
Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin.
Aguirre JD et al.
The Journal of Biological Chemistry, 2018
PINK1 and Parkin: emerging themes in mitochondrial homeostasis.
McWilliams TG et al.
Current Opinion in Cell Biology, 2017
Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation.
Pao KC et al.
Nature Chemical Biology, 2016
Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.
Ham SJ et al.
The Journal of Biological Chemistry, 2016
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Ordureau A et al.
Molecular Cell, 2014
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.
Kazlauskaite A et al.
Open Biology, 2014
A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.
Spratt DE et al.
Nature Communications, 2013
Autoregulation of Parkin activity through its ubiquitin-like domain.
Chaugule VK et al.
The Embo Journal, 2011
Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study.
Marder KS et al.
Archives of Neurology, 2010
Frequency of heterozygous Parkin mutations in healthy subjects: need for careful prospective follow-up examination of mutation carriers.
Brüggemann N et al.
Parkinsonism & Related Disorders, 2009
Risk of Parkinson disease in carriers of parkin mutations: estimation using the kin-cohort method.
Wang Y et al.
Archives of Neurology, 2008
Construction and validation of a Parkinson's disease mutation genotyping array for the Parkin gene.
Clark LN et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2007
Distribution, type, and origin of Parkin mutations: review and case studies.
Hedrich K et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2004
Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations.
Hedrich K et al.
Neurology, 2002
Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin.
Tomoo K et al.
Biochimica Et Biophysica Acta, 0