Varaico: Literature-Extracted Genetic Variants

Gene:PRKN
Variant:p.K27R
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PRKN

NM_004562.3:p.K27R

Associated Papers

E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.

Hao X et al.

The Embo Journal, 2025

Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.

Ito F et al.

Nature Communications, 2023

RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.

Liu W et al.

Advanced Science (weinheim, Baden-wurttemberg, Germany), 2023

36563124 (PubMed )
Supplement: ADVS-10-2203884-s001.pdf

HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.

Zhang G et al.

British Journal of Cancer, 2022

Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.

Liu JY et al.

Human Molecular Genetics, 2022

SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.

Nakagawa T et al.

Cell Reports, 2022

Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination.

Langerová H et al.

Cells, 2020

Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.

Birsa N et al.

The Journal of Biological Chemistry, 2014

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin.

Um JW et al.

Journal of Neuroscience Research, 2012

The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe.

Girdwood D et al.

Plos One, 2011

21655279 (PubMed )
Supplement: pone.0020089.s001.xls › Sheet1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."