Varaico: Literature-Extracted Genetic Variants

Gene:PRKN
Variant:p.G12D
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PRKN

NM_004562.3:p.G12D

Associated Papers

Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer.

Gebru MT et al.

Cancer Research, 2025

Regulation of lung cancer initiation and progression by the stem cell determinant Musashi.

Barber AG et al.

Elife, 2025

Diverse landscape of genetically engineered mouse models: Genomic and molecular insights into prostate cancer.

Kaushal JB et al.

Cancer Letters, 2024

The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability.

Abad E et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2024

Targeting Ras with protein engineering.

Tomazini A et al.

Oncotarget, 2023

Histological and Genetic Diversity in Ovarian Mucinous Carcinomas: A Pilot Study.

Razia S et al.

Current Oncology (toronto, Ont.), 2023

Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease.

Mansky RH et al.

Cell Reports, 2023

Comparative analysis of web-based programs for single amino acid substitutions in proteins.

Choudhury A et al.

Plos One, 2022

35507592 (PubMed )
Supplement: pone.0267084.s001.xlsx › HRAS

Mutation profile of non-small cell lung cancer revealed by next generation sequencing.

Chang YS et al.

Respiratory Research, 2021

Complete Screening of Exons 2, 3, and 4 of KRAS and NRAS Genes Reveals a Higher Number of Clinically Relevant Mutations than Food and Drug Administration Quantitative Polymerase Chain Reaction-Based Commercial Kits.

Sánchez-Ibarra HE et al.

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 2020

Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.

Mussazhanova Z et al.

Cancer Science, 2020

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells.

Testa U et al.

Cancers, 2018

30060526 (PubMed )
Supplement: cancers-10-00248-s001.docx

Mutational profiling of acral melanomas in Korean populations.

Shim JH et al.

Experimental Dermatology, 2017

Deregulation of Rho GTPases in cancer.

Porter AP et al.

Small Gtpases, 2016

KRAS, BRAF, and PIK3CA mutations, and patient prognosis in 126 pancreatic cancers: pyrosequencing technology and literature review.

Zhou L et al.

Medical Oncology (northwood, London, England), 2016

Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis.

Xie CM et al.

The Journal of Cell Biology, 2015

The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling.

Chakraborty A et al.

Nature Communications, 2015

Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalization.

Tan M et al.

Neoplasia (new York, N.y.), 2015

Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay.

Su J et al.

Chinese Journal of Cancer, 2014

Selection for Evi1 activation in myelomonocytic leukemia induced by hyperactive signaling through wild-type NRas.

Wolf S et al.

Oncogene, 2013

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

Baker DJ et al.

Nature Cell Biology, 2013

Detecting KRAS mutations in peripheral blood of colorectal cancer patients by peptide nucleic acid clamp PCR.

Miyano S et al.

Experimental and Therapeutic Medicine, 2012

Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

Vincent DF et al.

The American Journal of Pathology, 2012

[Comparison of different methods of molecular-genetic analysis of somatic mutations in K-ras gene in patients with colorectal cancer].

Amosenko FA et al.

Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 2012

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.

Wu J et al.

Proceedings of the National Academy of Sciences of the United States of America, 2011

PRKN, DJ-1, and PINK1 screening identifies novel splice site mutation in PRKN and two novel DJ-1 mutations.

Ghazavi F et al.

Movement Disorders : Official Journal of the Movement Disorder Society, 2011

Parkin Exon Rearrangements and Sequence Variants in LRRK2 Mutations Carriers: Analysis on a Possible Modifier Effect on LRRK2 Penetrance.

Solla P et al.

Parkinson's Disease, 2010

Molecular analysis of the parkin gene in South African patients diagnosed with Parkinson's disease.

Bardien S et al.

Parkinsonism & Related Disorders, 2009

Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor.

Pigullo S et al.

Parkinsonism & Related Disorders, 2004

Genomic Characterization of Low- and High-Grade Pancreatic Mucinous Cystic Neoplasms Reveals Recurrent KRAS Alterations in "High-Risk" Lesions.

Conner JR et al.

Pancreas, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."