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Varaico: Literature-Extracted Genetic Variants

Include likely false extractions

Gene:PRMT5

Variant:p.G438D

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PRMT5

NM_006109.5:p.G438D

hg38:chr14:22924070 C>T

Associated Papers

MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design.

Cottrell KM et al.

Journal of Medicinal Chemistry, 2025

39919252 (PubMed )

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers.

Cottrell KM et al.

Journal of Medicinal Chemistry, 2024

38595098 (PubMed )

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