Associated Papers
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells.
Gillespie MS et al.
Oncogene, 2025
PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.
Cai C et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2021
PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation.
Hwang JW et al.
Communications Biology, 2020
MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex.
Abe Y et al.
Communications Biology, 2019
30675521 (PubMed )
Supplement: 42003_2018_275_MOESM1_ESM.pdf
PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.
Chiang K et al.
Cell Reports, 2017
PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.
Clarke TL et al.
Molecular Cell, 2017
The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation.
Tarighat SS et al.
Leukemia, 2016
Inhibition of cardiomyocyte hypertrophy by protein arginine methyltransferase 5.
Chen M et al.
The Journal of Biological Chemistry, 2014
PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130.
Zhou Z et al.
Cell Research, 2010
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.
Lacroix M et al.
Embo Reports, 2008
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