Associated Papers
The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality.
Bray C et al.
Frontiers in Oncology, 2023
A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis.
Du C et al.
Cell Reports, 2019
Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.
Gerhart SV et al.
Scientific Reports, 2018
29946150 (PubMed )
Supplement: 41598_2018_28002_MOESM1_ESM.pdf
Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.
Braun CJ et al.
Cancer Cell, 2017
PRMT5 is required for cell-cycle progression and p53 tumor suppressor function.
Scoumanne A et al.
Nucleic Acids Research, 2009
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