Associated Papers
Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy.
Gatdula JRP et al.
Biorxiv : the Preprint Server for Biology, 2026
Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach.
Gharemirshamloo FR et al.
Journal of Cellular Biochemistry, 2023
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.
Sangeetham SB et al.
Scientific Reports, 2021
Biophysical characterization of oligomerization and fibrillization of the G131V pathogenic mutant of human prion protein.
Zhang M et al.
Acta Biochimica Et Biophysica Sinica, 2019
Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease.
Zheng Z et al.
Scientific Reports, 2018
Evidence for a central role of PrP helix 2 in the nucleation of amyloid fibrils.
Honda R et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2018
Structural mechanisms of oligomer and amyloid fibril formation by the prion protein.
Sengupta I et al.
Chemical Communications (cambridge, England), 2018
The G126V Mutation in the Mouse Prion Protein Hinders Nucleation-Dependent Fibril Formation by Slowing Initial Fibril Growth and by Increasing the Critical Concentration.
Sabareesan AT et al.
Biochemistry, 2017
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