Associated Papers
Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy.
Gatdula JRP et al.
Biorxiv : the Preprint Server for Biology, 2026
Genetic causes and modifiers of prion diseases.
Mead S et al.
The Lancet. Neurology, 2026
A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene.
Sampedro-Torres-Quevedo C et al.
Plos Pathogens, 2025
Genetic variability of the prion protein gene (PRNP) in thin-tailed and fat-tailed sheep.
Wicaksono A et al.
Open Veterinary Journal, 2025
Decoding Missense Variants by Incorporating Phase Separation via Machine Learning.
Feng M et al.
Nature Communications, 2024
Perspectives on CRISPR Genome Editing to Prevent Prion Diseases in High-Risk Individuals.
Medd MM et al.
Biomedicines, 2024
Neuropathologically directed profiling of PRNP somatic and germline variants in sporadic human prion disease.
McDonough GA et al.
Acta Neuropathologica, 2024
Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease.
McDonough GA et al.
Biorxiv : the Preprint Server for Biology, 2024
N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease.
Pasala C et al.
Biomolecules, 2024
The first meta-analysis of the G96S single nucleotide polymorphism (SNP) of the prion protein gene (PRNP) with chronic wasting disease in white-tailed deer.
Won SY et al.
Frontiers in Veterinary Science, 2024
Arg177 and Asp159 from dog prion protein slow liquid-liquid phase separation and inhibit amyloid formation of human prion protein.
Li XN et al.
The Journal of Biological Chemistry, 2023
Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds.
Sola D et al.
Veterinary Research, 2023
Novel Prion Protein Gene Polymorphisms in Awassi Sheep in Three Regions of the Fertile Crescent.
Rashaydeh FS et al.
Veterinary Sciences, 2023
A single protective polymorphism in the prion protein blocks cross-species prion replication in cultured cells.
Arshad H et al.
Journal of Neurochemistry, 2023
Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach.
Gharemirshamloo FR et al.
Journal of Cellular Biochemistry, 2023
Conformation-Dependent Influences of Hydrophobic Amino Acids in Two In-Register Parallel β-Sheet Amyloids, an α-Synuclein Amyloid and a Local Structural Model of PrPSc.
Otaki H et al.
Acs Omega, 2022
Prion protein gene mutation detection using long-read Nanopore sequencing.
Kroll F et al.
Scientific Reports, 2022
Engineered pegRNAs improve prime editing efficiency.
Nelson JW et al.
Nature Biotechnology, 2022
Prion Protein Biology Through the Lens of Liquid-Liquid Phase Separation.
Agarwal A et al.
Journal of Molecular Biology, 2022
Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles.
Castle AR et al.
Plos One, 2022
Genetic aspects of human prion diseases.
Appleby BS et al.
Frontiers in Neurology, 2022
Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein.
Gielnik M et al.
Scientific Reports, 2021
Structure of prion β-oligomers as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations.
Serpa JJ et al.
Proteomics, 2021
1H, 13C, 15N backbone and side-chain resonance assignments of the pathogenic G131V mutant of human prion protein (91-231).
Zhang Q et al.
Biomolecular Nmr Assignments, 2021
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.
Carlson GA et al.
International Journal of Molecular Sciences, 2021
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.
Sangeetham SB et al.
Scientific Reports, 2021
Association Study of the M132L Single Nucleotide Polymorphism With Susceptibility to Chronic Wasting Disease in Korean Elk: A Meta-Analysis.
Roh IS et al.
Frontiers in Veterinary Science, 2021
Structural effects of the highly protective V127 polymorphism on human prion protein.
Hosszu LLP et al.
Communications Biology, 2020
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.
Glynn C et al.
Nature Structural & Molecular Biology, 2020
Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds.
Teferedegn EY et al.
Bmc Veterinary Research, 2020
Neutralizing Mutations Significantly Inhibit Amyloid Formation by Human Prion Protein and Decrease Its Cytotoxicity.
Huang JJ et al.
Journal of Molecular Biology, 2020
A Transient Intermediate Populated in Prion Folding Leads to Domain Swapping.
Mondal B et al.
Biochemistry, 2020
Biophysical characterization of oligomerization and fibrillization of the G131V pathogenic mutant of human prion protein.
Zhang M et al.
Acta Biochimica Et Biophysica Sinica, 2019
Genetic Factors in Mammalian Prion Diseases.
Mead S et al.
Annual Review of Genetics, 2019
Search-and-replace genome editing without double-strand breaks or donor DNA.
Anzalone AV et al.
Nature, 2019
A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models.
Otero A et al.
Molecular Neurobiology, 2019
Atomic insight into prion disorder: An intricate detail gained by 0.5 μs molecular dynamics simulation of preventive G127V and deleterious D178V mutation in prion protein.
Gharemirshamlu FR et al.
Journal of Cellular Biochemistry, 2019
Mutations in Prion Protein Gene: Pathogenic Mechanisms in C-Terminal vs. N-Terminal Domain, a Review.
Bernardi L et al.
International Journal of Molecular Sciences, 2019
Detecting early stage structural changes in wild type, pathogenic and non-pathogenic prion variants using Markov state model.
Jani V et al.
Rsc Advances, 2019
Pressure Reveals Unique Conformational Features in Prion Protein Fibril Diversity.
Torrent J et al.
Scientific Reports, 2019
Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease.
Zheng Z et al.
Scientific Reports, 2018
Genetic PrP Prion Diseases.
Kim MO et al.
Cold Spring Harbor Perspectives in Biology, 2018