Varaico: Literature-Extracted Genetic Variants

Gene:PRNP
Variant:p.Q172R
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PRNP

NM_000311.5:p.Q172R

Associated Papers

A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC.

Kurt TD et al.

The Journal of Biological Chemistry, 2014

Discriminant analysis of prion sequences for prediction of susceptibility.

Lee JH et al.

Experimental & Molecular Medicine, 2013

Dominant-negative effects in prion diseases: insights from molecular dynamics simulations on mouse prion protein chimeras.

Cong X et al.

Journal of Biomolecular Structure & Dynamics, 2013

Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation.

DiSalvo S et al.

Nature Structural & Molecular Biology, 2011

Trans-dominant inhibition of prion propagation in vitro is not mediated by an accessory cofactor.

Geoghegan JC et al.

Plos Pathogens, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."