Varaico: Literature-Extracted Genetic Variants

Gene:PRNP
Variant:p.N174S
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PRNP

NM_000311.5:p.N174S

Associated Papers

Y225A induces long-range conformational changes in human prion protein that are protective in Drosophila.

Myers RR et al.

The Journal of Biological Chemistry, 2023

Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies.

Santarelli S et al.

Frontiers in Neuroscience, 2023

Intrinsic determinants of prion protein neurotoxicity in Drosophila: from sequence to (dys)function.

Cembran A et al.

Frontiers in Molecular Neuroscience, 2023

New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein.

Myers RR et al.

Disease Models & Mechanisms, 2022

Insight From Animals Resistant to Prion Diseases: Deciphering the Genotype - Morphotype - Phenotype Code for the Prion Protein.

Myers R et al.

Frontiers in Cellular Neuroscience, 2020

A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC.

Kurt TD et al.

The Journal of Biological Chemistry, 2014

N-terminal helix-cap in α-helix 2 modulates β-state misfolding in rabbit and hamster prion proteins.

Sweeting B et al.

Plos One, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."