Associated Papers
De novo nucleotide biosynthetic pathway and cancer.
Chen J et al.
Genes & Diseases, 2023
CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model.
Nguyen TTT et al.
Molecular Pharmacology, 2023
PRPS2 mutations drive acute lymphoblastic leukemia relapse through influencing PRPS1/2 hexamer stability.
Song L et al.
Blood Science (baltimore, Md.), 2023
Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5-Fluorouracil.
Wang D et al.
Journal of Cellular and Molecular Medicine, 2018
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.
Li X et al.
Nature Cell Biology, 2016
Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.
Li B et al.
Nature Medicine, 2015
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