Associated Papers
Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
Cohen I et al.
The Journal of Biological Chemistry, 2019
Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases.
Cohen I et al.
The Biochemical Journal, 2018
Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.
Cohen I et al.
The Biochemical Journal, 2016
Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates.
Alloy AP et al.
The Journal of Biological Chemistry, 2015
Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.
Salameh MA et al.
Protein Science : a Publication of the Protein Society, 2012
Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
Salameh MA et al.
The Journal of Biological Chemistry, 2010
Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin.
Salameh MA et al.
The Journal of Biological Chemistry, 2008
The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.
Pasternak A et al.
Protein Science : a Publication of the Protein Society, 2001
Activating a zymogen without proteolytic processing: mutation of Lys15 and Asn194 activates trypsinogen.
Pasternak A et al.
Biochemistry, 1998
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