Associated Papers
Loss of arginase 2 disrupts striatum-specific polyamine homeostasis.
Nalepa M et al.
The Febs Journal, 2026
HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs.
Draper D et al.
Neurobiology of Disease, 2026
Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.
Labra SR et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2026
Early functional changes and plasma GFAP in Swedish families with Autosomal Dominant Alzheimer's disease mutations.
Luckett ES et al.
Translational Psychiatry, 2026
Dyrk1a inhibition with the Novel Compound DYR533: A Cross-Disease Therapeutic Strategy Targeting Amyloidosis, Tau Pathogenesis, and Neuroinflammation.
Bartholomew SK et al.
Biorxiv : the Preprint Server for Biology, 2026
Proteins Associated with Cognition in Amyloid-beta Positive Elders Based on Cerebrospinal Fluid Proteomics.
Liu M et al.
Molecular Neurobiology, 2025
Pridopidine, a Potent and Selective Therapeutic Sigma-1 Receptor (S1R) Agonist for Treating Neurodegenerative Diseases.
Gershoni Emek N et al.
Pharmaceuticals (basel, Switzerland), 2025
Fshr gene depletion prevents recognition memory loss, fat accrual and bone loss in Alzheimer's mice.
Cheliadinova U et al.
Molecular Psychiatry, 2025
Pathological calcium influx through amyloid beta pores disrupts synaptic function.
Adeoye T et al.
Cell Calcium, 2025
Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer's disease models.
Montesinos J et al.
Biorxiv : the Preprint Server for Biology, 2025
A decade progress in the phenotyping of AppNL-G-F knock-in mouse model of Alzheimer's disease.
Manabe T et al.
Neuroscience Research, 2025
TSPO contributes to neuropathology and cognitive deficits in Alzheimer's disease.
Ceyzériat K et al.
Journal of Neuroinflammation, 2025
INPP5D/SHIP1 is a dual regulator of endo-lysosome function and selective phagocytosis in human microglia.
Terzioglu G et al.
Biorxiv : the Preprint Server for Biology, 2025
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis.
Augur ZM et al.
Acta Neuropathologica, 2025
Tau-Targeted Therapeutic Strategies: Mechanistic Targets, Clinical Pipelines, and Analysis of Failures.
Shen X et al.
Cells, 2025
Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.
Jadiya P et al.
Biorxiv : the Preprint Server for Biology, 2025
Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice.
Lin Y et al.
Cell Calcium, 2025
THICAPA modulates amyloid precursor protein processing and alleviates oxidative stress in fibroblasts derived from patients with Familial Alzheimer's disease.
Thangeswaran D et al.
Molecular Biology Reports, 2025
δ-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice.
Hinchliffe ES et al.
Biorxiv : the Preprint Server for Biology, 2025
Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.
Podleśny-Drabiniok A et al.
Cell Reports, 2025
Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids.
Labra SR et al.
Biorxiv : the Preprint Server for Biology, 2025
The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset.
Liu H et al.
Brain : a Journal of Neurology, 2025
Beyond the brain: early autonomic dysfunction in Alzheimer's disease.
Nanclares C et al.
Acta Neuropathologica Communications, 2025
Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life.
Latina V et al.
Acta Neuropathologica Communications, 2025
Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer disease.
Liu Q et al.
Autophagy, 2025
Targeting mitophagy in neurodegenerative diseases.
Antico O et al.
Nature Reviews. Drug Discovery, 2025
Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss.
Yeapuri P et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
Clinical Significance of Early-Onset Alzheimer's Mutations in Asian and Western Populations: A Scoping Review.
Poniah P et al.
Genes, 2025
Identification and characterization of variants in PSEN1, PSEN2, and APP genes in Chinese patients with early-onset Alzheimer's disease.
Nan H et al.
Alzheimer's Research & Therapy, 2025
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
Trambauer J et al.
Alzheimer's Research & Therapy, 2025
BOK-engaged mitophagy alleviates neuropathology in Alzheimer's disease.
Yang Y et al.
Brain : a Journal of Neurology, 2025
Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice.
Pfitzer J et al.
Journal of Neurochemistry, 2025
Case of early onset Alzheimer's disease associated with a novel PSEN1 variant identified in Colombia.
Zapata-Restrepo LM et al.
Npj Dementia, 2025
Organelle abnormalities in Alzheimer's disease.
Gao J et al.
Organelle (tucson, Ariz.), 2025
Arc mediates intercellular tau transmission via extracellular vesicles.
Tyagi M et al.
Biorxiv : the Preprint Server for Biology, 2024
Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations.
Wang J et al.
The Biochemical Journal, 2024
Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer's disease.
Qian Z et al.
Molecular Psychiatry, 2024
Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.
Sirkis DW et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration.
Majumder M et al.
Cells, 2024
Rodent Models of Alzheimer's Disease: Past Misconceptions and Future Prospects.
Collins HM et al.
International Journal of Molecular Sciences, 2024
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.
Vaillant-Beuchot L et al.
Cell Death & Disease, 2024
Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner.
Guo X et al.
Aging Cell, 2024
Innate immune activation in neurodegenerative diseases.
Castro-Gomez S et al.
Immunity, 2024
Swedish Alzheimer's disease variant perturbs activity of retrograde molecular motors and causes widespread derangement of axonal transport pathways.
Feole M et al.
The Journal of Biological Chemistry, 2024
Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Qiu Y et al.
Nature Structural & Molecular Biology, 2024
Neuropathological changes in the TASTPM mouse model of Alzheimer's disease and their relation to hyperexcitability and cortical spreading depolarization.
Gimeno-Ferrer F et al.
Scientific Reports, 2024
Cognitive impairment in Alzheimer's disease FAD4T mouse model: Synaptic loss facilitated by activated microglia via C1qA.
Zhang C et al.
Life Sciences, 2024