Associated Papers
ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer's disease mice - a new pharmacological target for Glu-related neurotoxicity.
Górska AM et al.
Progress in Neurobiology, 2026
Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss.
Suryadevara V et al.
Comprehensive Physiology, 2026
A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid β-peptide.
Nagarajan V et al.
Neurobiology of Disease, 2026
The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and therapeutic potential.
Abedin MJ et al.
Journal of Alzheimer's Disease : Jad, 2026
Structural and functional effects of disease mutations in the interface of human membrane protein complexes.
Ridha F et al.
International Journal of Biological Macromolecules, 2025
Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.
Podleśny-Drabiniok A et al.
Cell Reports, 2025
A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid β-peptide.
Nagarajan V et al.
Biorxiv : the Preprint Server for Biology, 2025
The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset.
Liu H et al.
Brain : a Journal of Neurology, 2025
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
Trambauer J et al.
Alzheimer's Research & Therapy, 2025
γ-secretase facilitates retromer-mediated retrograde transport.
Takeo Y et al.
Journal of Cell Science, 2025
Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice.
Cruz-Sese J et al.
Biorxiv : the Preprint Server for Biology, 2025
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone.
Catto F et al.
Plos One, 2025
Transmissible long-term neuroprotective and pro-cognitive effects of 1-42 beta-amyloid with A2T icelandic mutation in an Alzheimer's disease mouse model.
Célestine M et al.
Molecular Psychiatry, 2024
Mapping cellular stress and lipid dysregulation in Alzheimer-related progressive neurodegeneration using label-free Raman microscopy.
Haessler A et al.
Communications Biology, 2024
PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.
Perrin F et al.
Acta Neuropathologica Communications, 2024
Vascular Function and Ion Channels in Alzheimer's Disease.
Taylor JL et al.
Microcirculation (new York, N.y. : 1994), 2024
AlzDiscovery: A computational tool to identify Alzheimer's disease-causing missense mutations using protein structure information.
Pan Q et al.
Protein Science : a Publication of the Protein Society, 2024
ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.
Sato K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Primary lateral sclerosis associated with PSEN1 Pro284Leu variant in a Colombian family: Clinical and neuropathological features.
Acosta-Uribe J et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone.
Catto F et al.
Biorxiv : the Preprint Server for Biology, 2024
Complement C3aR signaling: Immune and metabolic modulation and its impact on Alzheimer's disease.
Gedam M et al.
European Journal of Immunology, 2024
Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology.
Miller B et al.
Aging Cell, 2024
Alzheimer's disease pathophysiology in the Retina.
Gaire BP et al.
Progress in Retinal and Eye Research, 2024
γ-secretase facilitates retromer-mediated retrograde transport.
Takeo Y et al.
Biorxiv : the Preprint Server for Biology, 2024
Engineering of a high-fidelity Cas12a nuclease variant capable of allele-specific editing.
Wei J et al.
Plos Biology, 2024
Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice.
Parvin F et al.
Acs Chemical Neuroscience, 2024
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.
Jackson RJ et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2024
Innate immune activation in neurodegenerative diseases.
Castro-Gomez S et al.
Immunity, 2024
Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes.
Devkota S et al.
Cell Reports, 2024
Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer's Disease and Other Neurodegenerative Diseases.
Sun Y et al.
International Journal of Molecular Sciences, 2024
Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease.
Srinivasan S et al.
Frontiers in Immunology, 2024
Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome.
Shaik SM et al.
Molecular Neurodegeneration, 2023
Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.
Vanova T et al.
Cell Reports, 2023
PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.
Perrin F et al.
Research Square, 2023
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
Yin Z et al.
Nature Immunology, 2023
A novel peptide derived from vascular endothelial growth factor prevents amyloid beta aggregation and toxicity.
Bouvet P et al.
Aging Cell, 2023
APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.
Jackson RJ et al.
Biorxiv : the Preprint Server for Biology, 2023
Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology.
Gomez-Sequeda N et al.
Scientific Reports, 2023
Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
Kurth V et al.
The Journal of Biological Chemistry, 2023