Associated Papers
Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes.
Fernández SG et al.
Molecular Neurodegeneration, 2025
40281586 (PubMed )
Supplement: 13024_2025_832_MOESM1_ESM.docx
Sequence of decline on the NIH-toolbox cognitive battery in a predominantly Latino sample with autosomal dominant Alzheimer's disease.
Petkus AJ et al.
Journal of Alzheimer's Disease : Jad, 2025
The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1.
Liu L et al.
Biorxiv : the Preprint Server for Biology, 2024
Age of onset predicted by Aβ profiling in a novel PSEN1 (I180F) mutation.
Robbie L et al.
Neuroscience Letters, 2024
Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
Petit D et al.
The Embo Journal, 2022
36121025 (PubMed )
Supplement: EMBJ-41-e111084-s001.pdf
Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease.
Dahl MJ et al.
Neurobiology of Aging, 2022
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