Associated Papers
Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
Petit D et al.
The Embo Journal, 2022
36121025 (PubMed )
Supplement: EMBJ-41-e111084-s001.pdf
Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.
Imai S et al.
Journal of Biochemistry, 2019
Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.
Futai E et al.
The Journal of Biological Chemistry, 2009
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