Associated Papers
Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.
Labra SR et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2026
Mitochondrial dysfunction and Ca2+ dysregulation in human iPSC-derived neurons carrying presenilin-1 mutation arise under stress via an MCU-1-independent mechanism.
Wilson C et al.
Scientific Reports, 2026
Glial and Neuronal Alzheimer's Disease-Related Alterations Reproduced in Human Induced Pluripotent Stem Cells With Presenilin-1 Mutation.
Comolli D et al.
Research Square, 2026
Clinical and functional evidence supporting the pathogenicity of the novel PSEN1 p.R358P variant in early-onset Alzheimer's disease.
García-Chialva DE et al.
Journal of Alzheimer's Disease : Jad, 2026
Neurodegenerative disease and autophagy in iPSC-based models.
Odonchimed S et al.
Neuroscience Research, 2026
Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neuropathology patterns.
Khandelwal P et al.
Biorxiv : the Preprint Server for Biology, 2025
Pluripotent stem cells-based neural organoids for modelling human brain development and diseases.
Tong L et al.
Cell & Bioscience, 2025
Elevated TFEB expression with limited activation in peripheral blood mononuclear cells reflects altered lysosomal enzyme dynamics in Parkinson's disease.
Mizutani Y et al.
Neurobiology of Disease, 2025
THICAPA modulates amyloid precursor protein processing and alleviates oxidative stress in fibroblasts derived from patients with Familial Alzheimer's disease.
Thangeswaran D et al.
Molecular Biology Reports, 2025
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.
Podleśny-Drabiniok A et al.
Cell Reports, 2025
The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset.
Liu H et al.
Brain : a Journal of Neurology, 2025
Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models.
Hribkova H et al.
Biorxiv : the Preprint Server for Biology, 2025
Beyond the brain: early autonomic dysfunction in Alzheimer's disease.
Nanclares C et al.
Acta Neuropathologica Communications, 2025
Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human-Induced Pluripotent Stem Cells.
Holloway K et al.
Aging Cell, 2025
Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier.
Takeuchi LE et al.
Neurobiology of Disease, 2025
Transthyretin as a therapeutic target: the future of disease-modifying therapies for Alzheimer's disease.
Shaw S et al.
Molecular Biology Reports, 2025
Mitochondrial dynamics and bioenergetics in Alzheimer's induced pluripotent stem cell-derived neurons.
MacMullen C et al.
Brain : a Journal of Neurology, 2025
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
Chou CC et al.
Nature Cell Biology, 2025
Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's disease.
Bansal VA et al.
Elife, 2025
Ide Copy Number Variant Does Not Influence Stroke Severity in 2 C57BL/6J Mouse Models nor in Humans: An Exploratory Study.
Foddis M et al.
Stroke, 2025
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
Trambauer J et al.
Alzheimer's Research & Therapy, 2025
Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses.
Laurie S et al.
Nature Medicine, 2025
Basal forebrain global functional connectivity is preserved in asymptomatic presenilin-1 E280A mutation carriers: Results from the Colombia cohort.
Grazia A et al.
The Journal of Prevention of Alzheimer's Disease, 2025
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
Chou CC et al.
Biorxiv : the Preprint Server for Biology, 2025
OAS1: A Protective Mechanism for Alzheimer's Disease? An Exploration of Data and Possible Mechanisms.
Elsworthy RJ et al.
International Journal of Molecular Sciences, 2025
Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes.
Elsworthy RJ et al.
Journal of Neurochemistry, 2025
Skin and Induced Pluripotent Stem Cells as Biomarkers for Neurodegenerative Diseases.
Rallis E et al.
Genes, 2024
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Khani M et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors.
Bagyinszky E et al.
International Journal of Molecular Sciences, 2024
TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport.
Wu H et al.
Nature Communications, 2024
Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations.
Wang J et al.
The Biochemical Journal, 2024
Comprehensive Overview of Alzheimer's Disease: Etiological Insights and Degradation Strategies.
Singh MK et al.
International Journal of Molecular Sciences, 2024
Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models.
Murakami R et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2024
Rodent Models of Alzheimer's Disease: Past Misconceptions and Future Prospects.
Collins HM et al.
International Journal of Molecular Sciences, 2024
Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Benzow K et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease.
Hori A et al.
Plos One, 2024
Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability.
Maksour S et al.
Frontiers in Cellular Neuroscience, 2024
Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.
Vanova T et al.
Cell Reports, 2023
Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease.
Lavekar SS et al.
Scientific Reports, 2023
The Proteome Profile of Olfactory Ecto-Mesenchymal Stem Cells-Derived from Patients with Familial Alzheimer's Disease Reveals New Insights for AD Study.
Rochín-Hernández LJ et al.
International Journal of Molecular Sciences, 2023
Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology.
Gomez-Sequeda N et al.
Scientific Reports, 2023