Associated Papers
Rare A360T Mutation Alters GSK3β(Ser9) Binding in the Cytosolic Loop of Presenilin 1, Influencing β-Catenin Nuclear Localization and Pro-Death Gene Expression in Alzheimer's Disease Case.
Wężyk M et al.
International Journal of Molecular Sciences, 2023
Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.
Grigorenko AP et al.
Oncotarget, 2017
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Wrigley JD et al.
Journal of Neurochemistry, 2004
Presenilin mutations associated with fronto-temporal dementia.
Hutton M
Annals of Neurology, 2004
Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion.
Palacino JJ et al.
The Journal of Biological Chemistry, 2001
Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.
Murphy MP et al.
The Journal of Biological Chemistry, 2000
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS et al.
Nature, 1999
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