Associated Papers
Presenilin-1 mutations in Alzheimer's disease: an update on genotype-phenotype relationships.
Larner AJ
Journal of Alzheimer's Disease : Jad, 2013
Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update.
Larner AJ et al.
Journal of Alzheimer's Disease : Jad, 2009
Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Ikeuchi T et al.
The Journal of Biological Chemistry, 2003
Gamma-secretase inhibitors and Alzheimer's disease.
Roberts SB
Advanced Drug Delivery Reviews, 2002
Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Ikeuchi T et al.
Neuromolecular Medicine, 2002
Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
Yu C et al.
The Journal of Biological Chemistry, 2001
Genetic markers in the diagnosis of Alzheimer's disease.
Rogaeva E et al.
Journal of Alzheimer's Disease : Jad, 2001
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.
Kulic L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2000
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