Associated Papers
Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
Fukumori A et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2010
Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.
Kim H et al.
The Journal of Biological Chemistry, 2005
Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.
Laudon H et al.
The Journal of Biological Chemistry, 2004
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