Associated Papers
Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein.
Do HN et al.
Communications Biology, 2023
Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.
Trambauer J et al.
Embo Reports, 2020
31762188 (PubMed )
Supplement: EMBR-21-e47996-s001.pdf
Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.
Grigorenko AP et al.
Oncotarget, 2017
Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.
Kretner B et al.
The Journal of Biological Chemistry, 2011
Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.
Pérez-Revuelta BI et al.
Journal of Neurochemistry, 2010
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
Sato C et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2006
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