Associated Papers
Molecular mechanism of substrate recognition and cleavage by human γ-secretase.
Guo X et al.
Science (new York, N.y.), 2024
Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
Kurth V et al.
The Journal of Biological Chemistry, 2023
Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk.
Raman S et al.
Neurobiology of Disease, 2020
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
Fleck D et al.
The Journal of Biological Chemistry, 2016
Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.
Honarnejad K et al.
Translational Psychiatry, 2014
Podoplanin is a substrate of presenilin-1/γ-secretase.
Yurrita MM et al.
The International Journal of Biochemistry & Cell Biology, 2014
Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.
Honarnejad K et al.
Journal of Cellular and Molecular Medicine, 2013
Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.
Stemmer N et al.
Plos One, 2013
Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.
Koch P et al.
The American Journal of Pathology, 2012
Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.
Lorenzen A et al.
Molecular Brain, 2010
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity.
Riedle S et al.
The Biochemical Journal, 2009
Presenilin-mediated signal transduction.
Cowburn RF et al.
Physiology & Behavior, 2007
Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.
Tanii H et al.
Journal of Neuroscience Research, 2006
SorLA signaling by regulated intramembrane proteolysis.
Böhm C et al.
The Journal of Biological Chemistry, 2006
Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.
Popescu BO et al.
The Journal of Biological Chemistry, 2004
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
Fluhrer R et al.
The Journal of Biological Chemistry, 2003
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
Lammich S et al.
The Journal of Biological Chemistry, 2002
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C et al.
The Journal of Cell Biology, 2002
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Steiner H et al.
Neurobiology of Disease, 2001
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch.
Capell A et al.
Nature Cell Biology, 2000
The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.
Jacobsen H et al.
The Journal of Biological Chemistry, 1999
Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
Steiner H et al.
Biochemistry, 1999
Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
Leimer U et al.
Biochemistry, 1999