Associated Papers
A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Heilig EA et al.
The Journal of Biological Chemistry, 2010
Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.
Fraering PC
Current Genomics, 2007
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Wang J et al.
Journal of Neurochemistry, 2006
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
Nakaya Y et al.
The Journal of Biological Chemistry, 2005
Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
Wang J et al.
Neurobiology of Disease, 2004
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