Associated Papers
Agomelatine drives sex-specific neuroprotection and reduced pathology in rat and human Alzheimer's models.
Terry GA et al.
Biorxiv : the Preprint Server for Biology, 2026
Neurodegenerative disease and autophagy in iPSC-based models.
Odonchimed S et al.
Neuroscience Research, 2026
A neuroimmune cerebral assembloid model to study the pathophysiology of familial Alzheimer's disease.
Becerra-Calixto A et al.
Journal of Neuroinflammation, 2025
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.
Khawaja RR et al.
Nature Cell Biology, 2025
Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer's disease.
Ogg J et al.
Acta Neuropathologica, 2025
Presence of Alzheimer's disease variants in circular RNA of PSEN1 and PSEN2.
Johnson IP et al.
Journal of Alzheimer's Disease : Jad, 2025
Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.
Podleśny-Drabiniok A et al.
Cell Reports, 2025
The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset.
Liu H et al.
Brain : a Journal of Neurology, 2025
Protective genetic variants against Alzheimer's disease.
Marino C et al.
The Lancet. Neurology, 2025
Benchmarking AlphaMissense pathogenicity predictions against APP, PSEN1, and PSEN2 variants of unknown significance.
Pillai J et al.
Biochemistry and Biophysics Reports, 2025
Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier.
Takeuchi LE et al.
Neurobiology of Disease, 2025
Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes.
Fernández SG et al.
Molecular Neurodegeneration, 2025
Presenilin, γ-Secretase, and the Search for Pathogenic Triggers of Alzheimer's Disease.
Wolfe MS
Biochemistry, 2025
Mitochondrial dynamics and bioenergetics in Alzheimer's induced pluripotent stem cell-derived neurons.
MacMullen C et al.
Brain : a Journal of Neurology, 2025
Evaluating pathogenicity of variants of unknown significance in APP, PSEN1, and PSEN2.
Marsh JA et al.
Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics, 2025
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia.
Llibre-Guerra JJ et al.
Nature Medicine, 2025
Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project.
Wang D et al.
Journal of Alzheimer's Disease : Jad, 2025
Clinical Significance of Early-Onset Alzheimer's Mutations in Asian and Western Populations: A Scoping Review.
Poniah P et al.
Genes, 2025
Ide Copy Number Variant Does Not Influence Stroke Severity in 2 C57BL/6J Mouse Models nor in Humans: An Exploratory Study.
Foddis M et al.
Stroke, 2025
Basal forebrain global functional connectivity is preserved in asymptomatic presenilin-1 E280A mutation carriers: Results from the Colombia cohort.
Grazia A et al.
The Journal of Prevention of Alzheimer's Disease, 2025
The Spectrum of Genetic Risk in Alzheimer Disease.
Karagas N et al.
Neurology. Genetics, 2025
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease.
Valdes P et al.
Alzheimer's Research & Therapy, 2025
Sex-related differences in genetically determined Alzheimer's disease.
Del Hoyo Soriano L et al.
Frontiers in Aging Neuroscience, 2025
Organelle abnormalities in Alzheimer's disease.
Gao J et al.
Organelle (tucson, Ariz.), 2025
The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1.
Liu L et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits.
Perdok A et al.
Nature Communications, 2024
Frequency of Variants in Mendelian Alzheimer's Disease Genes within the Alzheimer's Disease Sequencing Project (ADSP).
Wang D et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
A Novel Rare PSEN2 Val226Ala in PSEN2 in a Korean Patient with Atypical Alzheimer's Disease, and the Importance of PSEN2 5th Transmembrane Domain (TM5) in AD Pathogenesis.
Yang Y et al.
International Journal of Molecular Sciences, 2024
Production of a heterozygous exon skipping model of common marmosets using gene-editing technology.
Sato K et al.
Lab Animal, 2024
PSEN2 Mutations May Mimic Frontotemporal Dementia: Two New Case Reports and a Review.
Minguillón Pereiro AM et al.
Biomedicines, 2024
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Gao C et al.
Molecular Neurobiology, 2024
The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1.
Liu L et al.
Biorxiv : the Preprint Server for Biology, 2024
Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Benzow K et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Mesenchymal Stem Cells from Familial Alzheimer's Patients Express MicroRNA Differently.
Rochín-Hernández LJ et al.
International Journal of Molecular Sciences, 2024
iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype.
Sullivan MA et al.
Journal of Neuroinflammation, 2024
JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer's disease.
Scopa C et al.
Nature Communications, 2023
Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.
Vanova T et al.
Cell Reports, 2023
Clinical considerations in early-onset cerebral amyloid angiopathy.
Banerjee G et al.
Brain : a Journal of Neurology, 2023
Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease.
Lavekar SS et al.
Scientific Reports, 2023
Genetic Phenotypes of Alzheimer's Disease: Mechanisms and Potential Therapy.
Quan M et al.
Phenomics (cham, Switzerland), 2023
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway.
Guo Y et al.
Nature Communications, 2023
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.
Novotny BC et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2023
BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions.
Nakatsu D et al.
Stem Cell Reports, 2023