Associated Papers
Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.
Cermáková K et al.
Cancer Research, 2014
Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD.
Vets S et al.
Molecular Therapy. Nucleic Acids, 2013
Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors.
Schrijvers R et al.
Aids (london, England), 2013
Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo.
Koh Y et al.
Aids (london, England), 2013
LEDGF (p75) promotes DNA-end resection and homologous recombination.
Daugaard M et al.
Nature Structural & Molecular Biology, 2012
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.
Hare S et al.
Plos Pathogens, 2009
An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.
Merad H et al.
Plos One, 2009
Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.
Shun MC et al.
Journal of Virology, 2008
Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.
McKee CJ et al.
The Journal of Biological Chemistry, 2008
Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.
Maertens GN et al.
Journal of Cell Science, 2006
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.
Cherepanov P et al.
Nature Structural & Molecular Biology, 2005
Predicting nsSNPs that Disrupt Protein-Protein Interactions Using Docking.
Goodacre N et al.
Ieee/acm Transactions on Computational Biology and Bioinformatics, 0
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