Associated Papers
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.
Tibarewal P et al.
Disease Models & Mechanisms, 2026
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer.
Serebriiskii IG et al.
Npj Genomic Medicine, 2023
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN.
Chakraborty S et al.
Journal of Cell Science, 2023
Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination.
Iwase R et al.
Journal of the American Chemical Society, 2023
Nuclear PTEN's Functions in Suppressing Tumorigenesis: Implications for Rare Cancers.
Langdon CG
Biomolecules, 2023
The HECT family of E3 ubiquitin ligases and PTEN.
Song MS et al.
Seminars in Cancer Biology, 2022
TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer.
He YM et al.
Acta Pharmacologica Sinica, 2022
Generating a new mouse model for nuclear PTEN deficiency by a single K13R mutation.
Kato T et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2021
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C et al.
Cell Death and Differentiation, 2021
Nuclear PTEN deficiency and heterozygous PTEN loss have distinct impacts on brain and lymph node size.
Igarashi A et al.
Biochemical and Biophysical Research Communications, 2021
Nuclear PTEN and p53 suppress stress-induced liver cancer through distinct mechanisms.
Kato T et al.
Biochemical and Biophysical Research Communications, 2021
The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.
Kato T et al.
Iscience, 2020
PTEN in Autism and Neurodevelopmental Disorders.
Rademacher S et al.
Cold Spring Harbor Perspectives in Medicine, 2019
Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.
Igarashi A et al.
The Journal of Biological Chemistry, 2018
Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.
Yang JM et al.
Oncogene, 2017
Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.
Gupta A et al.
The Journal of Biological Chemistry, 2016
Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.
Stumpf M et al.
Plos One, 2016
Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.
Nguyen HN et al.
Scientific Reports, 2015
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.
Lee MS et al.
Nature Communications, 2015
A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.
Gil A et al.
Plos One, 2015
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.
Guo H et al.
Cell Reports, 2012
Ubiquitination regulates PTEN nuclear import and tumor suppression.
Trotman LC et al.
Cell, 2007
PTEN enters the nucleus by diffusion.
Liu F et al.
Journal of Cellular Biochemistry, 2005